Serum zinc and risk of type 2 diabetes incidence in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

Yary, Teymoor, Virtanen, Jyrki K, Ruusunen, Anu, Tuomainen, Tomi-Pekka and Voutilainen, Sari 2016, Serum zinc and risk of type 2 diabetes incidence in men: the Kuopio Ischaemic Heart Disease Risk Factor Study, Journal of trace elements in medicine and biology, vol. 33, pp. 120-124, doi: 10.1016/j.jtemb.2015.11.001.

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Title Serum zinc and risk of type 2 diabetes incidence in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
Author(s) Yary, Teymoor
Virtanen, Jyrki K
Ruusunen, AnuORCID iD for Ruusunen, Anu orcid.org/0000-0002-1169-7478
Tuomainen, Tomi-Pekka
Voutilainen, Sari
Journal name Journal of trace elements in medicine and biology
Volume number 33
Start page 120
End page 124
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-01
ISSN 0946-672X
Keyword(s) serum zinc
type 2 diabetes
C-reactive protein
Summary Objectives
Zinc may play a role in the development of type 2 diabetes (T2D), because it is involved in antioxidant and anti-inflammatory activities. However, the role of zinc in the etiology of T2D has been poorly investigated. This study was conducted to study the association of serum zinc on T2D risk in middle-aged and older Finnish men.

Methods
This was a 20-year prospective follow-up study on 2220 Finnish men from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) who were 42 to 60 years old at baseline in 1984–1989. The main outcome was incident T2D. Serum zinc, body mass index (BMI), fasting blood glucose (FBG), serum insulin, C-reactive protein (CRP) and, in a subset of 751 participants, insulin-like growth factor-binding protein-1 (IGFBP-1), were measured. Also, the homeostatic model assessment (HOMA) was used to quantify insulin resistance (HOMA-IR), beta-cell function (HOMA-β) and insulin sensitivity (HOMA-IS).

Results
At baseline, serum zinc was associated with higher BMI, serum insulin, HOMA-IR, HOMA-β and IGFBP-1 and lower HOMA-IS. During the average follow-up of 19.3 years, 416 men developed T2D. Men in the highest quartile of serum zinc had 60% higher risk (95% CI 20–113%; P-trend < 0.001) for incident T2D compared with the men in the lowest quartile, after multivariate adjustments. This association was attenuated after adjustment for BMI (HR = 1.39, 95% CI 1.04–1.85; P-trend = 0.013) or HOMA-IS (HR = 1.38, 95% CI 1.04–1.83; P-trend = 0.015), whereas adjustment for the other factors had only modest impact on the association.

Conclusion
Higher serum zinc was associated with higher risk of T2D; effects of zinc on BMI and insulin sensitivity may partly explain the association. Further prospective studies are warranted to confirm our results and explore potential mechanisms.
Language eng
DOI 10.1016/j.jtemb.2015.11.001
Field of Research 0601 Biochemistry And Cell Biology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier GmbH
Persistent URL http://hdl.handle.net/10536/DRO/DU:30097650

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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