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A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

Chia, J. S. J., McRae, J. L., Kukuljan, S., Woodford, K., Elliott, R. B., Swinburn, B. and Dwyer, K. M. 2017, A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes, Nutrition & diabetes, vol. 7, no. 5, pp. 1-7, doi: 10.1038/nutd.2017.16.

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Title A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes
Author(s) Chia, J. S. J.
McRae, J. L.
Kukuljan, S.
Woodford, K.
Elliott, R. B.
Swinburn, B.
Dwyer, K. M.ORCID iD for Dwyer, K. M. orcid.org/0000-0002-4376-9720
Journal name Nutrition & diabetes
Volume number 7
Issue number 5
Article ID e274
Start page 1
End page 7
Total pages 7
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2017-05-15
ISSN 2044-4052
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
Summary Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially other influencing factors underpins disease progression. We present evidence that A1 β-casein cows' milk protein is a primary causal trigger of type 1 diabetes in individuals with genetic risk factors. Permissive gut factors (for example, aberrant mucosal immunity), intervene by impacting the gut's environment and the mucosal barrier. Various influencing factors (for example, breastfeeding duration, exposure to other dietary triggers and vitamin D) modify the impact of triggers and permissive gut factors on disease. The power of the dominant trigger and permissive gut factors on disease is influenced by timing, magnitude and/or duration of exposure. Within this framework, removal of a dominant dietary trigger may profoundly affect type 1 diabetes incidence. We present epidemiological, animal-based, in vitro and theoretical evidence for A1 β-casein and its β-casomorphin-7 derivative as dominant causal triggers of type 1 diabetes. The effects of ordinary milk containing A1 and A2 β-casein and milk containing only the A2 β-casein warrant comparison in prospective trials.
Language eng
DOI 10.1038/nutd.2017.16
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099425

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.