Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex Eastwood, Justin R, Ribot, Raoul FH, Rollins, Lee Ann, Buchanan, Katherine L, Walder, Ken, Bennett, Andrew TD and Berg, Mathew L 2017, Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex, Scientific reports, vol. 7, pp. 1-11, doi: 10.1038/s41598-017-13476-z. Attached Files Name Description MIMEType Size Downloads eastwood-hostheterozygosity-2017.pdf Published version application/pdf 1.64MB 108 Title Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex Author(s) Eastwood, Justin R Ribot, Raoul FH orcid.org/0000-0003-3869-8873 Rollins, Lee Ann orcid.org/0000-0002-3279-7005 Buchanan, Katherine L orcid.org/0000-0002-6648-5819 Walder, Ken orcid.org/0000-0002-6758-4763 Bennett, Andrew TD orcid.org/0000-0001-8512-2805 Berg, Mathew L orcid.org/0000-0002-5774-3089 Journal name Scientific reports Volume number 7 Article ID 13310 Start page 1 End page 11 Total pages 11 Publisher Nature Publishing Group Place of publication London, Eng. Publication date 2017-10 ISSN 2045-2322 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics Summary Genetic diversity at community, population and individual levels is thought to influence the spread of infectious disease. At the individual level, inbreeding and heterozygosity are associated with increased risk of infection and disease severity. Host genotype rarity may also reduce infection risk if pathogens are co-adapted to common or local hosts, but to date, no studies have investigated the relative importance of genotype rarity and heterozygosity for infection in a wild, sexually reproducing vertebrate. With beak and feather disease virus (BFDV) infection in a wild parrot (Platycercus elegans), we show that both heterozygosity and genotype rarity of individual hosts predicted infection, but in contrasting ways. Heterozygosity was negatively associated with probability of infection, but not with infection load. In contrast, increased host genotype rarity was associated with lower viral load in infected individuals, but did not predict infection probability. These effects were largely consistent across subspecies, but were not evident at the population level. Subspecies and age were also strongly associated with infection. Our study provides novel insights into infection dynamics by quantifying rarity and diversity simultaneously. We elucidate roles that host genetic diversity can play in infection dynamics, with implications for understanding population divergence, intraspecific diversity and conservation. Language eng DOI 10.1038/s41598-017-13476-z Field of Research 060503 Microbial Genetics 070712 Veterinary Virology HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2017, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30103019 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Centre for Integrative Ecology Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 05 Oct 2017, 17:10:42 EST Fri, 06 Oct 2017, 04:01:17 EST Fri, 27 Oct 2017, 08:23:36 EST Sat, 28 Oct 2017, 05:06:21 EST Wed, 01 Nov 2017, 08:07:34 EST Wed, 01 Nov 2017, 08:10:54 EST Tue, 21 Nov 2017, 14:37:14 EST Fri, 07 Sep 2018, 12:58:42 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 17 times in Scopus Search Google Scholar Access Statistics: 485 Abstract Views, 109 File Downloads  -  Detailed Statistics Created: Fri, 27 Oct 2017, 08:23:36 EST

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