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[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

Martin, Ana Carolina B.M., Fuzer, Angelina M., Becceneri, Amanda B., da Silva, James Almada, Tomasin, Rebeka, Denoyer, Delphine, Kim, Soo-Hyun, McIntyre, Katherine A., Pearson, Helen B., Yeo, Belinda, Nagpal, Aadya, Ling, Xiawei, Selistre-de-Araujo, Heloisa S., Vieira, Paulo Cezar, Cominetti, Marcia R. and Pouliot, Normand 2017, [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo, Oncotarget, vol. 8, no. 42, pp. 72260-72271, doi: 10.18632/oncotarget.20139.

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Title [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo
Author(s) Martin, Ana Carolina B.M.
Fuzer, Angelina M.
Becceneri, Amanda B.
da Silva, James Almada
Tomasin, Rebeka
Denoyer, DelphineORCID iD for Denoyer, Delphine orcid.org/0000-0001-8932-5116
Kim, Soo-Hyun
McIntyre, Katherine A.
Pearson, Helen B.
Yeo, Belinda
Nagpal, Aadya
Ling, Xiawei
Selistre-de-Araujo, Heloisa S.
Vieira, Paulo Cezar
Cominetti, Marcia R.
Pouliot, Normand
Journal name Oncotarget
Volume number 8
Issue number 42
Start page 72260
End page 72271
Total pages 12
Publisher Impact journals LLC
Place of publication Albany, N.Y.
Publication date 2017-09-22
ISSN 1949-2553
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Oncology
Cell Biology
gingerol
breast cancer
cell cycle
apoptosis
animal models
Summary There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin (Zingiber officinale Roscoe) have been shown to mediate anti-tumour activity and to contribute to the anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties of ginger. Here we report on the inhibitory properties of [10]-gingerol against metastatic triple negative breast cancer (TNBC) in vitro and in vivo. We show that [10]-gingerol concentration-dependently induces apoptotic death in mouse and human TNBC cell lines in vitro. In addition, [10]-gingerol is well tolerated in vivo, induces a marked increase in caspase-3 activation and inhibits orthotopic tumour growth in a syngeneic mouse model of spontaneous breast cancer metastasis. Importantly, using both spontaneous and experimental metastasis assays, we show for the first time that [10]-gingerol significantly inhibits metastasis to multiple organs including lung, bone and brain. Remarkably, inhibition of brain metastasis was observed even when treatment was initiated after surgical removal of the primary tumour. Taken together, these results indicate that [10]-gingerol may be a safe and useful complementary therapy for the treatment of metastatic breast cancer and warrant further investigation of its efficacy, either alone or in combination with standard systemic therapies, in pre-clinical models of metastatic breast cancer and in patients.
Language eng
DOI 10.18632/oncotarget.20139
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
060103 Cell Development, Proliferation and Death
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103117

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.