Turning natural adaptations to oncogenic factors into an ally in the war against cancer Vittecoq, Marion, Giraudeau, Mathieu, Sepp, Tuul, Marcogliese, David J., Klaassen, Marcel, Renaud, Francois, Ujvari, Beata and Thomas, Frederic 2018, Turning natural adaptations to oncogenic factors into an ally in the war against cancer, Evolutionary applications, vol. 11, no. 6, pp. 836-844, doi: 10.1111/eva.12608. Attached Files Name Description MIMEType Size Downloads klaassen-turningnatural-2018.pdf Published version application/pdf 586.84KB 71 Title Turning natural adaptations to oncogenic factors into an ally in the war against cancer Author(s) Vittecoq, Marion Giraudeau, Mathieu Sepp, Tuul Marcogliese, David J. Klaassen, Marcel orcid.org/0000-0003-3907-9599 Renaud, Francois Ujvari, Beata orcid.org/0000-0003-2391-2988 Thomas, Frederic Journal name Evolutionary applications Volume number 11 Issue number 6 Start page 836 End page 844 Total pages 9 Publisher John Wiley & Sons Place of publication Chichester, Eng. Publication date 2018-07 ISSN 1752-4563 1752-4571 Keyword(s) cancer resistance ecotoxicolgy experimental evolution pollution wildlife ecotoxicology Science & Technology Life Sciences & Biomedicine Evolutionary Biology KILLIFISH FUNDULUS-HETEROCLITUS ARYL-HYDROCARBON RECEPTOR PERCH PERCA-FLAVESCENS NAKED MOLE-RAT GENETIC DIVERSITY UV-RADIATION ENVIRONMENTAL RADIATION EVOLUTIONARY TOXICOLOGY POPULATION-STRUCTURE CHIRONOMUS-RIPARIUS Summary Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression. Building on a substantial knowledge base from the literature, we here present and discuss this progressive and promising research direction, advocating closer collaboration between the fields of medicine, ecology, and evolution in the war against cancer. Language eng DOI 10.1111/eva.12608 Field of Research 0603 Evolutionary Biology HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2018, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30107981 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Centre for Integrative Ecology Related Links Link Description Connect to published version (open access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 27 Apr 2018, 15:18:11 EST Sat, 28 Apr 2018, 05:01:05 EST Sat, 28 Apr 2018, 06:06:51 EST Wed, 02 May 2018, 11:07:30 EST Wed, 02 May 2018, 11:09:55 EST Wed, 02 May 2018, 11:11:02 EST Sat, 30 Jun 2018, 02:32:07 EST Fri, 03 Aug 2018, 14:04:12 EST Fri, 03 Aug 2018, 14:07:53 EST Fri, 03 Aug 2018, 14:08:42 EST Thu, 09 Aug 2018, 13:35:12 EST Fri, 07 Sep 2018, 19:11:32 EST Filtered Full Citation counts:   Cited 10 times in TR Web of Science Cited 9 times in Scopus Search Google Scholar Access Statistics: 373 Abstract Views, 74 File Downloads  -  Detailed Statistics Created: Fri, 27 Apr 2018, 15:18:11 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.