Openly accessible

Mitochondrial agents for bipolar disorder

Pereira, Ciria, Chavarria, Victor, Vian, Joao, Ashton, Melanie Maree, Berk, Michael, Marx, Wolfgang and Dean, Olivia May 2018, Mitochondrial agents for bipolar disorder, International journal of neuropsychopharmacology, vol. 21, no. 6, pp. 550-569, doi: 10.1093/ijnp/pyy018.

Attached Files
Name Description MIMEType Size Downloads
ashton-mitochondrialagents-2018.pdf Published version application/pdf 285.96KB 96

Title Mitochondrial agents for bipolar disorder
Author(s) Pereira, Ciria
Chavarria, Victor
Vian, Joao
Ashton, Melanie MareeORCID iD for Ashton, Melanie Maree
Berk, MichaelORCID iD for Berk, Michael
Marx, WolfgangORCID iD for Marx, Wolfgang
Dean, Olivia MayORCID iD for Dean, Olivia May
Journal name International journal of neuropsychopharmacology
Volume number 21
Issue number 6
Start page 550
End page 569
Total pages 20
Publisher Oxford Academic
Place of publication London, Eng.
Publication date 2018-06
ISSN 1469-5111
Keyword(s) adjunctive
bipolar disorder
complimentary therapies
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Pharmacology & Pharmacy
Neurosciences & Neurology
Summary Background
Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit.

This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder. A and ANZCTR search was conducted for complete and ongoing trials on mitochondrial agents used in psychiatric disorders. A PubMed search was also conducted for literature published between January 1981 and July 2017. Systematic reviews, randomized controlled trials, observational studies, case series, and animal studies with an emphasis on agents affecting mitochondrial function and its role in bipolar disorder were included. The search was augmented by manually searching the references of key papers and related literature. The results were presented as a narrative review.

Mitochondrial agents offer new horizons in mood disorder treatment. While some negative effects have been reported, most compounds are overall well tolerated and have generally benign side-effect profiles.

The study of neuroinflammation, neurodegeneration, and mitochondrial function has contributed the understanding of bipolar disorder’s pathophysiology. Agents targeting these pathways could be a potential therapeutic strategy. Future directions include identification of novel candidate mitochondrial modulators as well as rigorous and well-powered clinical trials.
Language eng
DOI 10.1093/ijnp/pyy018
Field of Research 110999 Neurosciences not elsewhere classified
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in TR Web of Science
Scopus Citation Count Cited 20 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 354 Abstract Views, 97 File Downloads  -  Detailed Statistics
Created: Thu, 31 May 2018, 19:23:05 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact