Increased severity and spread of Mycobacterium ulcerans, Southeastern Australia Tai, Alex Y.C., Athan, Eugene, Friedman, N. Deborah, Hughes, Andrew, Walton, Aaron and O'Brien, Daniel P. 2018, Increased severity and spread of Mycobacterium ulcerans, Southeastern Australia, Emerging infectious diseases, vol. 24, no. 1, pp. 58-64, doi: 10.3201/eid2401.171070. Attached Files Name Description MIMEType Size Downloads athan-increasedseverity-2018.pdf Published version application/pdf 1.32MB 132 Title Increased severity and spread of Mycobacterium ulcerans, Southeastern Australia Formatted title Increased severity and spread of Mycobacterium ulcerans, Southeastern Australia Author(s) Tai, Alex Y.C. Athan, Eugene orcid.org/0000-0001-9838-6471 Friedman, N. Deborah orcid.org/0000-0003-2049-3087 Hughes, Andrew Walton, Aaron O'Brien, Daniel P. orcid.org/0000-0001-5418-3330 Journal name Emerging infectious diseases Volume number 24 Issue number 1 Start page 58 End page 64 Total pages 7 Publisher Centers for Disease Control and Prevention Place of publication Atlanta, Ga. Publication date 2018-01 ISSN 1080-6040 1080-6059 Keyword(s) Australia Buruli ulcer Mycobacteria ulcerans Mycobacteria ulcerans disease bacteria severe disease severity spread tuberculosis and other mycobacteria zoonoses Adult Aged Female Humans Male Middle Aged Mycobacterium ulcerans Severity of Illness Index Victoria Summary Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998–May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease. Risk factors associated with severe disease included age, time period (range of years of diagnosis), and location of lesions over a joint. We highlight the changing epidemiology and pathogenicity of M. ulcerans disease in Australia. Further research, including genomic studies of emergent strains with increased pathogenicity, is urgently needed to improve the understanding of this disease to facilitate implementation of effective public health measures to halt its spread. Language eng DOI 10.3201/eid2401.171070 Field of Research 1108 Medical Microbiology 1117 Public Health And Health Services 1103 Clinical Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©This work is in the Public Domain and has no copyright restriction Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30110108 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version (open access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 09 Jul 2018, 11:09:39 EST Mon, 09 Jul 2018, 13:39:18 EST Mon, 09 Jul 2018, 13:54:06 EST Thu, 30 Aug 2018, 06:03:43 EST Mon, 03 Sep 2018, 15:45:36 EST Mon, 03 Sep 2018, 15:49:13 EST Mon, 03 Sep 2018, 15:50:11 EST Tue, 04 Sep 2018, 10:50:17 EST Fri, 07 Sep 2018, 19:23:22 EST Filtered Full Citation counts:   Cited 29 times in TR Web of Science Cited 33 times in Scopus Search Google Scholar Access Statistics: 374 Abstract Views, 132 File Downloads  -  Detailed Statistics Created: Mon, 09 Jul 2018, 11:09:39 EST