Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review

Marx, Wolfgang M, Teleni, Laisa, McCarthy, Alexandra L, Vitetta, Luis, McKavanagh, Dan, Thomson, Damien and Isenring, Elisabeth 2013, Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review, Nutrition reviews, vol. 71, no. 4, pp. 245-254, doi: 10.1111/nure.12016.

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Title Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review
Author(s) Marx, Wolfgang MORCID iD for Marx, Wolfgang M
Teleni, Laisa
McCarthy, Alexandra L
Vitetta, Luis
McKavanagh, Dan
Thomson, Damien
Isenring, Elisabeth
Journal name Nutrition reviews
Volume number 71
Issue number 4
Start page 245
End page 254
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2013-04-01
ISSN 0029-6643
Keyword(s) antiemetics
antineoplastic agents
plant extracts
treatment outcome
chemotherapy regimen
science & technology
life sciences & biomedicine
nutrition & dietetics
Summary Chemotherapy-induced nausea and vomiting (CINV) is a common side-effect of cytotoxic treatment. It continues to affect a significant proportion of patients despite the widespread use of antiemetic medication. In traditional medicine, ginger (Zingiber officinale) has been used to prevent and treat nausea in many cultures for thousands of years. However, its use has not been confirmed in the chemotherapy context. To determine the potential use of ginger as a prophylactic or treatment for CINV, a systematic literature review was conducted. Reviewed studies comprised randomized controlled trials or crossover trials that investigated the anti-CINV effect of ginger as the sole independent variable in chemotherapy patients. Seven studies met the inclusion criteria. All studies were assessed on methodological quality and their limitations were identified. Studies were mixed in their support of ginger as an anti-CINV treatment in patients receiving chemotherapy, with three demonstrating a positive effect, two in favor but with caveats, and two showing no effect on measures of CINV. Future studies are required to address the limitations identified before clinical use can be recommended.
Language eng
DOI 10.1111/nure.12016
Field of Research 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, International Life Sciences Institute
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Document type: Journal Article
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