The role of epigenetic change in autism spectrum disorders Loke, Yuk Jing, Hannan, Anthony John and Craig, Jeffrey Mark 2015, The role of epigenetic change in autism spectrum disorders, Frontiers in neurology, vol. 6, pp. 1-18, doi: 10.3389/fneur.2015.00107. Attached Files Name Description MIMEType Size Downloads craig-roleofepigenetic-2015.pdf Published version application/pdf 1.68MB 155 Title The role of epigenetic change in autism spectrum disorders Author(s) Loke, Yuk Jing Hannan, Anthony John Craig, Jeffrey Mark orcid.org/0000-0003-3979-7849 Journal name Frontiers in neurology Volume number 6 Article ID 107 Start page 1 End page 18 Total pages 18 Publisher Frontiers Place of publication Lausanne, Switzerland Publication date 2015-05 ISSN 1664-2295 Keyword(s) epigenetics methylation autism spectrum disorders epigenomics gene expression Summary Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders characterized by problems with social communication, social interaction, and repetitive or restricted behaviors. ASD are comorbid with other disorders including attention deficit hyperactivity disorder, epilepsy, Rett syndrome, and Fragile X syndrome. Neither the genetic nor the environmental components have been characterized well enough to aid diagnosis or treatment of non-syndromic ASD. However, genome-wide association studies have amassed evidence suggesting involvement of hundreds of genes and a variety of associated genetic pathways. Recently, investigators have turned to epigenetics, a prime mediator of environmental effects on genomes and phenotype, to characterize changes in ASD that constitute a molecular level on top of DNA sequence. Though in their infancy, such studies have the potential to increase our understanding of the etiology of ASD and may assist in the development of biomarkers for its prediction, diagnosis, prognosis, and eventually in its prevention and intervention. This review focuses on the first few epigenome-wide association studies of ASD and discusses future directions. Language eng DOI 10.3389/fneur.2015.00107 Field of Research 1109 Neurosciences 1103 Clinical Sciences 1701 Psychology HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2015 Loke, Hannan and Craig. Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30110771 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version (open access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 10 Jul 2018, 11:02:22 EST Tue, 10 Jul 2018, 11:19:37 EST Tue, 10 Jul 2018, 11:31:41 EST Thu, 30 Aug 2018, 06:04:29 EST Mon, 03 Sep 2018, 09:25:50 EST Mon, 03 Sep 2018, 09:29:52 EST Mon, 03 Sep 2018, 10:52:51 EST Fri, 07 Sep 2018, 19:23:02 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 139 times in Scopus Search Google Scholar Access Statistics: 376 Abstract Views, 155 File Downloads  -  Detailed Statistics Created: Tue, 10 Jul 2018, 11:02:22 EST