The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia Ashton, Melanie M, Dean, Olivia M, Walker, Adam J, Bortolasci, Chiara C, Ng, Chee H, Hopwood, Malcolm, Harvey, Brian H, Möller, Marisa, McGrath, John J, Marx, Wolfgang, Turner, Alyna, Dodd, Seetal, Scott, James G, Khoo, Jon-Paul, Walder, Ken, Sarris, Jerome and Berk, Michael 2019, The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia, Frontiers in psychiatry, vol. 10, pp. 1-17, doi: 10.3389/fpsyt.2019.00115. Attached Files Name Description MIMEType Size Downloads Title The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia Author(s) Ashton, Melanie M orcid.org/0000-0001-6832-4157 Dean, Olivia M orcid.org/0000-0002-2776-3935 Walker, Adam J orcid.org/0000-0002-5399-1245 Bortolasci, Chiara C orcid.org/0000-0002-0794-6363 Ng, Chee H Hopwood, Malcolm Harvey, Brian H Möller, Marisa McGrath, John J Marx, Wolfgang Turner, Alyna orcid.org/0000-0001-7389-2546 Dodd, Seetal orcid.org/0000-0002-7918-4636 Scott, James G Khoo, Jon-Paul Walder, Ken Sarris, Jerome Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Frontiers in psychiatry Volume number 10 Article ID 115 Start page 1 End page 17 Total pages 17 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2019-03 ISSN 1664-0640 Keyword(s) bipolar disorder inflammation mangosteen pericarp mitochondria oxidative stress psychiatry schizophrenia Science & Technology Life Sciences & Biomedicine Summary New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders. Language eng DOI 10.3389/fpsyt.2019.00115 Field of Research 110999 Neurosciences not elsewhere classified Socio Economic Objective 920199 Clinical Health (Organs HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2019, Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30120251 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 29 Mar 2019, 07:46:23 EST Fri, 29 Mar 2019, 10:47:19 EST Tue, 30 Apr 2019, 16:05:49 EST Wed, 01 May 2019, 16:16:00 EST Wed, 01 May 2019, 16:18:08 EST Wed, 01 May 2019, 16:18:50 EST Sat, 15 Jun 2019, 02:32:05 EST Fri, 15 Nov 2019, 04:37:19 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 15 times in Scopus Search Google Scholar Access Statistics: 493 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 29 Mar 2019, 07:46:23 EST