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Probiotics, prematurity and neurodevelopment: Follow-up of a randomised trial

Jacobs, SE, Hickey, L, Donath, S, Opie, GF, Anderson, PJ, Garland, SM, Cheong, JLY, Gold, L, Sia, KL, Tobin, JM, Tabrizi, SN, Pirotta, M, Tang, MLK, Morley, CJ, Tan, K, Lewis, A, Veldman, A, Carse, E, Travadi, J, Wright, IMR, Osborn, DA, Sinn, J, Bowen, J, Levison, J, Stack, JA, DePaoli, AG, Austin, NC, Darlow, BA, Alsweiler, JM and Buksh, MJ 2017, Probiotics, prematurity and neurodevelopment: Follow-up of a randomised trial, BMJ Paediatrics Open, vol. 1, no. 1, pp. 1-9, doi: 10.1136/bmjpo-2017-000176.

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Title Probiotics, prematurity and neurodevelopment: Follow-up of a randomised trial
Author(s) Jacobs, SE
Hickey, L
Donath, S
Opie, GF
Anderson, PJ
Garland, SM
Cheong, JLY
Gold, LORCID iD for Gold, L orcid.org/0000-0002-2733-900X
Sia, KL
Tobin, JM
Tabrizi, SN
Pirotta, M
Tang, MLK
Morley, CJ
Tan, K
Lewis, A
Veldman, A
Carse, E
Travadi, J
Wright, IMR
Osborn, DA
Sinn, J
Bowen, J
Levison, J
Stack, JA
DePaoli, AG
Austin, NC
Darlow, BA
Alsweiler, JM
Buksh, MJ
Journal name BMJ Paediatrics Open
Volume number 1
Issue number 1
Article ID e000176
Start page 1
End page 9
Total pages 9
Publisher BMJ
Place of publication London, Eng.
Publication date 2017-11-25
ISSN 2399-9772
Keyword(s) Neurodevelopment
ProPremsStudy Groups
Summary Objective: To determine the impact of one probiotics combination on the neurodevelopment of very preterm children at 2–5 years corrected gestational age (CA). Design: Follow-up study of survivors of a double-blinded, placebo-controlled, randomised trial of probiotic effects on late-onset sepsis in very preterm infants that found reduced necrotising enterocolitis. Setting: 10 tertiary perinatal centres in Australia and New Zealand. Patients: 1099 very preterm infants born <32 weeks’ gestation and weighing <1500 g. Intervention: Probiotics (Bifidobacterium infantis, Streptococcus thermophilus and Bifidobacterium lactis) or placebo administered from birth until discharge home or term CA, whichever came sooner. Main outcome measures: Major neurodevelopmental impairment comprised any of moderate/severe cerebral palsy (Gross Motor Function Classification System score 2–5), motor impairment (Bayley-III Motor Composite Scale <–2SD or Movement Assessment Battery for Children <15th centile if ≫42 months’ CA), cognitive impairment (Bayley-III Composite Cognitive or Language Scales <–2SD or Wechsler Preschool and Primary Scale of Intelligence Full Scale Intelligence Quotient <–2SD if ≫42 months’ CA), blindness or deafness. Results: Outcome data were available for 735 (67%) participants, with 71 deaths and 664/1028 survivors assessed at a mean age of 30 months. Survival free of major neurodevelopmental impairment was comparable between groups (probiotics 281 (75.3%) vs placebo 271 (74.9%); relative risk 1.01 (95% CI 0.93 to 1.09)). Rates of deafness were lower in probiotic-treated children (0.6% vs 3.4%). Conclusion: Administration of the probiotics combination Bifidobacterium infantis, Streptococcus thermophilus and Bifidobacterium lactis to very preterm babies from soon after birth until discharge home or term CA did not adversely affect neurodevelopment or behaviour in early childhood.
Language eng
DOI 10.1136/bmjpo-2017-000176
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, Article author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120628

Document type: Journal Article
Collections: Faculty of Health
Population Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.