Statins and inflammation: new therapeutic opportunities in psychiatry Kim, Sung-Wan, Kang, Hee-Ju, Jhon, Min, Kim, Ju-Wan, Lee, Ju-Yeon, Walker, Adam, Agustini, Bruno, Kim, Jae-Min and Berk, Michael 2019, Statins and inflammation: new therapeutic opportunities in psychiatry, Frontiers in psychiatry, vol. 10, doi: 10.3389/fpsyt.2019.00103. Attached Files Name Description MIMEType Size Downloads Title Statins and inflammation: new therapeutic opportunities in psychiatry Author(s) Kim, Sung-Wan Kang, Hee-Ju Jhon, Min Kim, Ju-Wan Lee, Ju-Yeon Walker, Adam orcid.org/0000-0002-5399-1245 Agustini, Bruno Kim, Jae-Min Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Frontiers in psychiatry Volume number 10 Article ID 103 Total pages 16 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2019-03 ISSN 1664-0640 Keyword(s) dementia depression inflammation schizophrenia statin Science & Technology Life Sciences & Biomedicine Psychiatry C-REACTIVE PROTEIN MAJOR DEPRESSIVE DISORDER LIPID-LOWERING DRUGS N-ACETYL CYSTEINE DOUBLE-BLIND ALZHEIMERS-DISEASE CHOLESTEROL LEVELS COGNITIVE FUNCTION CORONARY ATHEROSCLEROSIS ANTIINFLAMMATORY AGENTS Summary Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders. Language eng DOI 10.3389/fpsyt.2019.00103 HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2019, Kim, Kang, Jhon, Kim, Lee, Walker, Agustini, Kim and Berk. Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30120656 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 11 Apr 2019, 15:14:06 EST Fri, 12 Apr 2019, 05:03:55 EST Wed, 22 May 2019, 06:04:57 EST Thu, 23 May 2019, 15:57:45 EST Thu, 23 May 2019, 16:00:48 EST Sat, 15 Jun 2019, 02:32:01 EST Fri, 15 Nov 2019, 05:40:46 EST Filtered Full Citation counts:   Cited 34 times in TR Web of Science Cited 37 times in Scopus Search Google Scholar Access Statistics: 441 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Thu, 11 Apr 2019, 15:14:06 EST