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Tomato and lycopene consumption is inversely associated with total and cause-specific mortality: A population-based cohort study, on behalf of the International Lipid Expert Panel (ILEP)

Mazidi, Mohsen, Katsiki, Niki, George, Elena S and Banach, Maciej 2020, Tomato and lycopene consumption is inversely associated with total and cause-specific mortality: A population-based cohort study, on behalf of the International Lipid Expert Panel (ILEP), British journal of nutrition, vol. 124, no. 12, pp. 1303-1310, doi: 10.1017/S0007114519002150.

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Title Tomato and lycopene consumption is inversely associated with total and cause-specific mortality: A population-based cohort study, on behalf of the International Lipid Expert Panel (ILEP)
Author(s) Mazidi, Mohsen
Katsiki, Niki
George, Elena SORCID iD for George, Elena S orcid.org/0000-0002-1385-2371
Banach, Maciej
Journal name British journal of nutrition
Volume number 124
Issue number 12
Start page 1303
End page 1310
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2020
ISSN 0007-1145
1475-2662
Keyword(s) BLOOD-PRESSURE
Cardio-metabolic risk factors
CARDIOVASCULAR-DISEASE
Cerebrovascular disease
CHD
DIETARY PATTERNS
Life Sciences & Biomedicine
Lycopene
Mortality
NATIONAL-HEALTH
Nutrition & Dietetics
OXIDATIVE STRESS
PROPENSITY SCORE
RISK
Science & Technology
SUPPLEMENTATION
SYSTEMIC INFLAMMATION
Tomatoes
VITAMIN-C
Summary No data exist on the associations of dietary tomato and lycopene consumption with total and cause-specific mortality. Using the National Health and Nutrition Examination Surveys 1999–2010, we evaluted the long-term impact of tomato and lycopene intake on total and cause-specific (CHD and cerebrovascular disease) mortality. We also assessed the changes in cardio-metabolic risk factors according to tomato and lycopene intake. Vital status to 31 December 2011 was ascertained. Cox proportional hazard regression models (followed by propensity score matching) were used to investigate the link between tomato and lycopene consumption total, CHD and cerebrovascular mortality. Among the 23 935 participants included (mean age = 47·6 years, 48·8 % men), 3403 deaths occurred during 76·4 months of follow-up. Tomato intake was inversely associated with total (risk ratio (RR) 0·86, 95 % CI 0·81, 0·92), CHD (RR 0·76, 95 % CI 0·70, 0·85) and cerebrovascular (RR 0·70, 95 % CI 0·62, 0·81) mortality. Similar inverse associations were found between lycopene consumption, total (RR 0·76, 95 % CI 0·72, 0·81), CHD (RR 0·73, 95 % CI 0·65, 0·83) and cerebrovascular (RR 0·71, 95 % CI 0·65, 0·78) mortality; these associations were independent of anthropometric, clinical and nutritional parameters. Age and obesity did not affect the association of tomato and lycopene consumption with total, CHD and cerebrovascular mortality. C-reactive protein significantly moderated the link between lycopene and tomato intake with total, CHD and cerebrovascular mortality. ANCOVA showed that participants with a higher tomato and lycopene consumption had a more cardio-protective profile compared with those with a lower intake. Our results highlighted the favourable effect of tomato and lycopene intake on total and cause-specific mortality as well as on cardio-metabolic risk factors. These findings should be taken into consideration for public health strategies
Language eng
DOI 10.1017/S0007114519002150
Indigenous content off
Field of Research 0702 Animal Production
0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, the authors
Free to Read? Yes
Free to Read Start Date 2020-02-23
Persistent URL http://hdl.handle.net/10536/DRO/DU:30129346

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.