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The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity

Mazidi, M, Kengne, AP, George, E and Siervo, M 2021, The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity, British Journal of Nutrition, vol. 125, no. 9, pp. 1043-1050, doi: 10.1017/S0007114519002149.

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Title The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity
Author(s) Mazidi, M
Kengne, AP
George, EORCID iD for George, E orcid.org/0000-0002-1385-2371
Siervo, M
Journal name British Journal of Nutrition
Volume number 125
Issue number 9
Start page 1043
End page 1050
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2021-05-14
ISSN 0007-1145
1475-2662
Keyword(s) Adiposity
Glucose haemostasis
Inflammation
Insulin resistance
Life Sciences & Biomedicine
Meat intake
Nutrition & Dietetics
Science & Technology
Summary AbstractWe explored the role of lipid accumulation products and visceral adiposity on the association between red meat consumption (RMC) and markers of insulin resistance (IR) and inflammation in USA adults. Data on RMC and health outcome measurements were extracted from the 2005–2010 US National Health and Nutrition Examination Surveys. Overall 16 621 participants were included in the analysis (mean age = 47·1 years, 48·3 % men). ANCOVA and ‘conceptus causal mediation’ models were applied while accounting for survey design. In adjusted models, a lower RMC was significantly associated with a cardio-protective profile of IR and inflammation. BMI had significant mediation effects on the association between RMC and C-reactive protein (CRP), apo B, fasting blood glucose (FBG), insulin, homoeostatic model assessment of IR and β-cell function, glycated Hb (HbA1c), TAG:HDL ratio and TAG glucose (TyG) index (all Ps < 0·05). Both waist circumference and anthropometrically predicted visceral adipose tissue mediated the association between RMC and CRP, FBG, HbA1c, TAG:HDL ratio and TyG index (all Ps < 0·05). Our findings suggest that adiposity, particularly the accumulation of abdominal fat, accounts for a significant proportion of the associations between red meat consumption, IR and inflammation.
Language eng
DOI 10.1017/S0007114519002149
Indigenous content off
Field of Research 0702 Animal Production
0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, the authors
Free to Read? Yes
Free to Read Start Date 2020-02-23
Persistent URL http://hdl.handle.net/10536/DRO/DU:30129347

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.