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The vulnerability to suicidal behavior is associated with reduced connectivity strength

Bijttebier, S, Caeyenberghs, K, van den Ameele, H, Achten, E, Rujescu, D, Titeca, K and van Heeringen, C 2015, The vulnerability to suicidal behavior is associated with reduced connectivity strength, Frontiers in Human Neuroscience, vol. 9, pp. 1-11, doi: 10.3389/fnhum.2015.00632.

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Title The vulnerability to suicidal behavior is associated with reduced connectivity strength
Author(s) Bijttebier, S
Caeyenberghs, KORCID iD for Caeyenberghs, K orcid.org/0000-0001-7009-6843
van den Ameele, H
Achten, E
Rujescu, D
Titeca, K
van Heeringen, C
Journal name Frontiers in Human Neuroscience
Volume number 9
Article ID 632
Start page 1
End page 11
Total pages 11
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2015-11-30
ISSN 1662-5161
Keyword(s) suicidal behavior
predisposition
connectivity strength
network based analysis
5-HTTLPR
MAOA
whole brain tractography
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Neurosciences
Psychology
Neurosciences & Neurology
TRAUMATIC BRAIN-INJURY
TENSOR IMAGING TRACTOGRAPHY
CORPUS-CALLOSUM
INTERHEMISPHERIC INTERACTION
VISUAL INFORMATION
FIBER TRACTOGRAPHY
COGNITIVE CONTROL
DIFFUSION MRI
RATING-SCALE
DEPRESSION
Summary Suicidal behavior constitutes a major public health problem. Based on the stress-diathesis model, biological correlates of a diathesis might help to predict risk after stressor-exposure. Structural changes in cortical and subcortical areas and their connections have increasingly been linked with the diathesis. The current study identified structural network changes associated with a diathesis using a whole-brain approach by examining the structural connectivity between regions in euthymic suicide attempters (SA). In addition, the association between connectivity measures, clinical and genetic characteristics was investigated. We hypothesized that SA showed lower connectivity strength, associated with an increased severity of general clinical characteristics and an elevated expression of short alleles in serotonin polymorphisms. Thirteen euthymic SA were compared with fifteen euthymic non-attempters and seventeen healthy controls (HC). Clinical characteristics and three serotonin-related genetic polymorphisms were assessed. Diffusion MRI together with anatomical scans were administered. Preprocessing was performed using Explore DTI. Whole brain tractography of the diffusion-weighted images was followed by a number of streamlines-weighted network analysis using NBS. The network analysis revealed decreased connectivity strength in SA in the connections between the left olfactory cortex and left anterior cingulate gyrus. Furthermore, SA had increased suicidal ideation, hopelessness and self-reported depression, but did not show any differences for the genetic polymorphisms. Finally, lower connectivity strength between the right calcarine fissure and the left middle occipital gyrus was associated with increased trait anxiety severity (rs = -0.78, p < 0.01) and hopelessness (rs = -0.76, p < 0.01). SA showed differences in white matter network connectivity strength associated with clinical characteristics. Together, these variables could play an important role in predicting suicidal behavior.
Language eng
DOI 10.3389/fnhum.2015.00632
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Bijttebier, Caeyenberghs, van den Ameele, Achten, Rujescu, Titeca and van Heeringen
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30133966

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.