Improving the mixing process of dry powder inhaler formulations with the iron oxide colour method Desai, K, Stewart, P, Morton, David and Hapgood, Karen 2016, Improving the mixing process of dry powder inhaler formulations with the iron oxide colour method, in Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting, AIChE,, pp. 224-231. Title Improving the mixing process of dry powder inhaler formulations with the iron oxide colour method Author(s) Desai, K Stewart, P Morton, David orcid.org/0000-0002-1491-6517 Hapgood, Karen orcid.org/0000-0002-0402-8954 Conference name AIChE Annual Meeting 2016 Conference location San Francisco, CA, USA Conference dates 2016/11/13 - 2016/11/18 Title of proceedings Particle Technology Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting Publication date 2016 Start page 224 End page 231 Total pages 8 Publisher AIChE Summary Blending of one or more powders is critical for many pharmaceutical powders, including formulations used for Dry Powder Inhalers. Dry powder inhalers (DPIs) are mixed dry powder medications (asthma) administered via the lungs (pulmonary route). DPIs generally comprise 1% of API and 99% lactose and are mixed in a tumbler mixer or a high shear mixer. Due to empirical nature of commercial production there are production issues such as failed batches, content uniformity issues, and product performance failures, especially low inhalation efficiency values. This leads to production and economic losses but also a lack of understanding in the blending process. The iron oxide colour method (IOCM) is a recent technique that involved mixing 1% of red iron oxide and 99% of lactose in different mixers and observing the colour [1]. The colour of the blend indicates how mixed the blend is; as the mixing time continues the blend colour changes from pink to red to orange; this method helps to understand the mixing process and the quality of mixing. This work follows on with the method by mixing and testing DPI formulations. Actual DPI blends, 99% DPI grade lactose and 1% API (salbutamol sulphate) are mixed in a high shear mixer (1L KG5) and samples are taken for time points of the blend and are checked with their corresponding colour points. This study investigates whether this colour method (IOCM) can predict or determine how much mixing is required for a Dry Powder Inhaler (DPI) blend (lactose/drug) to attain content uniformity (Real standard deviation (RSD) < 5). A High Shear Mixer (HSM) is used to mix DPI blends and samples were taken at different time points for different speeds and the content uniformity was tested. These time points were then compared with their corresponding colour points (lactose/iron oxide) to see if there is a correlation between colour points and content uniformity. ISBN 9781510834446 Indigenous content off HERDC Research category E3.1 Extract of paper Persistent URL http://hdl.handle.net/10536/DRO/DU:30134948 Document type: Conference Paper Collections: Faculty of Science, Engineering and Built Environment PVC's Office - Science and Technology Related Links Link Description Publisher URL Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 12 Feb 2020, 08:38:59 EST Thu, 13 Feb 2020, 04:00:54 EST Thu, 13 Feb 2020, 05:04:07 EST Fri, 05 Nov 2021, 16:07:55 EST Sat, 06 Nov 2021, 14:18:43 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 12 Abstract Views  -  Detailed Statistics Created: Wed, 12 Feb 2020, 08:38:59 EST