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Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis

Abegaz, TM, Bahagavathula, AS, Gebreyohannes, EA, Mekonnen, Alemayehu and Abebe, TB 2017, Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis, BMC Cardiovascular Disorders, vol. 17, no. 1, pp. 1-12, doi: 10.1186/s12872-017-0729-5.

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Title Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis
Author(s) Abegaz, TM
Bahagavathula, AS
Gebreyohannes, EA
Mekonnen, AlemayehuORCID iD for Mekonnen, Alemayehu orcid.org/0000-0002-6826-4817
Abebe, TB
Journal name BMC Cardiovascular Disorders
Volume number 17
Issue number 1
Article ID 291
Start page 1
End page 12
Total pages 12
Publisher BMC
Place of publication London, Eng.
Publication date 2017-12-12
ISSN 1471-2261
Keyword(s) Infective endocarditis
Long-term mortality
Meta-analysis
Short-term mortality
Summary Background: Despite advances in medical knowledge, technology and antimicrobial therapy, infective endocarditis (IE) is still associated with devastating outcomes. No reviews have yet assessed the outcomes of IE patients undergoing short- and long-term outcome evaluation, such as all-cause mortality and IE-related complications. We conducted a systematic review and meta-analysis to examine the short- and long-term mortality, as well as IE-related complications in patients with definite IE. Methods: A computerized systematic literature search was carried out in PubMed, Scopus and Google Scholar from 2000 to August, 2016. Included studies were published studies in English that assessed short-and long-term mortality for adult IE patients. Pooled estimations with 95% confidence interval (CI) were calculated with DerSimonian-Laird (DL) random-effects model. Sensitivity and subgroup analyses were also performed. Publication bias was evaluated using inspection of funnel plots and statistical tests. Results: Twenty five observational studies (retrospective, 14; prospective, 11) including 22,382 patients were identified. The overall pooled mortality estimates for IE patients who underwent short- and long-term follow-up were 20% (95% CI: 18.0–23.0, P < 0.01) and 37% (95% CI: 27.0–48.0, P < 0.01), respectively. The pooled prevalence of cardiac complications in patients with IE was found to be 39% (95%CI: 32.0–46.0) while septic embolism and renal complications accounted for 25% (95% CI: 20.0–31) and 19% (95% CI: 14.0–25.0) (all P < 0.01), respectively. Conclusion: Irrespective of the follow-up period, a significantly higher mortality rate was reported in IE patients, and the burden of IE-related complications were immense. Further research is needed to assess the determinants of overall mortality in IE patients, as well as well-designed observational studies to conform our results.
Language eng
DOI 10.1186/s12872-017-0729-5
Indigenous content off
Field of Research 1102 Cardiorespiratory Medicine and Haematology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136677

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Citation counts: TR Web of Science Citation Count  Cited 13 times in TR Web of Science
Scopus Citation Count Cited 17 times in Scopus
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.