Dosage form designs for the controlled drug release of solid dispersions

Tran, Phuong H.L. and Tran, Thao TD 2020, Dosage form designs for the controlled drug release of solid dispersions, International journal of pharmaceutics, vol. 581, pp. 1-8, doi: 10.1016/j.ijpharm.2020.119274.

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Title Dosage form designs for the controlled drug release of solid dispersions
Author(s) Tran, Phuong H.L.ORCID iD for Tran, Phuong H.L.
Tran, Thao TD
Journal name International journal of pharmaceutics
Volume number 581
Start page 1
End page 8
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2020-05-15
ISSN 0378-5173
Keyword(s) Solid dispersion
Controlled release
Poorly water-soluble drug
Drug delivery
Summary Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersions can be incorporated in general solid dosage forms such as powders, granules, capsules and tablets, but only to enhance solubility and the dissolution rate. However, further development of solid dispersions will be required in certain circumstances for further in vivo drug improvement of those solid dosage forms. In the current review, specific designs of solid dosage forms for controlled drug release will be reported. Moreover, methods and strategies for incorporating these solid dispersions into controlled drug release forms will also be discussed. Overall, the outlook of current studies will provide potential approaches for the further improvement of solid dispersions, especially for clinical developments in pharmaceutical therapy.
Language eng
DOI 10.1016/j.ijpharm.2020.119274
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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