Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin

Nguyen, KT, Tran, H. L. Phuong, Ngo, HV and Tran, TTD 2021, Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin, Anti-Cancer Agents in Medicinal Chemistry, vol. 21, no. 5, doi: 10.2174/1871520620666200407124020.

Title Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin
Author(s) Nguyen, KT
Tran, H. L. PhuongORCID iD for Tran, H. L. Phuong
Ngo, HV
Tran, TTD
Journal name Anti-Cancer Agents in Medicinal Chemistry
Volume number 21
Issue number 5
Publisher Bentham Science Publishers Ltd.
Place of publication San Francisco, Calif.
Publication date 2021
ISSN 1871-5206
Keyword(s) Film-forming hydrogel
film-forming nanogels
sustained release
Summary Background: Although film-forming hydrogels possess the advantages of both film andhydrogel dosage forms, certain limitations still remain. Objective:This study aims to investigate theuse of film-forming hydrogels and the effects of nanocarriers on the sustained release of a poorlywater-soluble drug, curcumin. Methods: The film-forming hydrogels contained either zein orpolyvinylpyrrolidone as a film former, in addition to hydroxypropyl methylcellulose, oleic acid,ethanol and water. Curcumin was encapsulated in poly(lactic-co-glycolic acid) and gelatinenanoparticles using a sonoprecipitation method. Free drug and drug-loaded nanoparticles were laterdispersed into blank hydrogels to produce the film-forming nanogels. Results: The results suggestedthat the encapsulation of curcumin in nanoparticles could reduce the drug particle size to less than200nm for easier diffusion and could shield curcumin from chemical interactions that limit its topicalpermeability. curcumin was more compatible with gelatine nanoparticles than with poly(lactic-coglycolic acid) nanoparticles, and gelatine nanoparticles, in turn, were more compatible with zein thanwith polyvinylpyrrolidone film-forming nanogels. Therefore, gelatine nanoparticles in zein filmforming nanogels greatly elevated the permeability of curcumin by over five times that afforded bygelatine nanoparticles in polyvinylpyrrolidone film-forming nanogels. Conclusion:This researchsuggested that film-forming nanogel is a promising drug delivery system for both improvedpermeability and sustained topical diffusion of the extremely hydrophobic drug curcumin dependingon the compatibility between the nanocarrier and the film-forming hydrogel.
Language eng
DOI 10.2174/1871520620666200407124020
Indigenous content off
Field of Research 0304 Medicinal and Biomolecular Chemistry
1112 Oncology and Carcinogenesis
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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