Attenuation of maternal weight gain impacts infant birthweight: systematic review and meta-analysis

Bennett, CJ, Walker, RE, Blumfield, ML, Ma, J, Wang, F, Wan, Y, Gwini, Stella May and Truby, H 2019, Attenuation of maternal weight gain impacts infant birthweight: systematic review and meta-analysis, Journal of developmental origins of health and disease, vol. 10, no. 4, pp. 387-405, doi: 10.1017/S2040174418000879.

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Title Attenuation of maternal weight gain impacts infant birthweight: systematic review and meta-analysis
Author(s) Bennett, CJ
Walker, RE
Blumfield, ML
Ma, J
Wang, F
Wan, Y
Gwini, Stella MayORCID iD for Gwini, Stella May orcid.org/0000-0002-0295-4575
Truby, H
Journal name Journal of developmental origins of health and disease
Volume number 10
Issue number 4
Start page 387
End page 405
Total pages 19
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2019-08
ISSN 2040-1744
2040-1752
Keyword(s) birthweight
gestational weight gain
macrosomia and large for gestational age
pregnancy
Summary Despite many interventions aiming to reduce excessive gestational weight gain (GWG), it is currently unclear the impact on infant anthropometric outcomes. The aim of this review was to evaluate offspring anthropometric outcomes in studies designed to reduce GWG. A systematic search of seven international databases, one clinical trial registry and three Chinese databases was conducted without date limits. Studies were categorised by intervention type: diet, physical activity (PA), lifestyle (diet + PA), other, gestational diabetes mellitus (GDM) (diet, PA, lifestyle, metformin and other). Meta-analyses were reported as weighted mean difference (WMD) for birthweight and birth length, and risk ratio (RR) for small for gestational age (SGA), large for gestational age (LGA), macrosomia and low birth weight (LBW). Collectively, interventions reduced birthweight, risk of macrosomia and LGA by 71 g (WMD: -70.67, 95% CI -101.90 to -39.43, P<0.001), 16% (RR: 0.84, 95% CI 0.73-0.98, P=0.026) and 19% (RR: 0.81, 95% CI 0.69-0.96, P=0.015), respectively. Diet interventions decreased birthweight and LGA by 99 g (WMD -98.80, 95% CI -178.85 to -18.76, P=0.016) and 65% (RR: 0.35, 95% CI 0.17-0.72, P=0.004). PA interventions reduced the risk of macrosomia by 51% (RR: 0.49, 95% CI 0.26-0.92, P=0.036). In women with GDM, diet and lifestyle interventions reduced birthweight by 211 and 296 g, respectively (WMD: -210.93, 95% CI -374.77 to -46.71, P=0.012 and WMD:-295.93, 95% CI -501.76 to -90.10, P=0.005, respectively). Interventions designed to reduce excessive GWG lead to a small reduction in infant birthweight and risk of macrosomia and LGA, without influencing the risk of adverse outcomes including LBW and SGA.
Language eng
DOI 10.1017/S2040174418000879
Indigenous content off
Field of Research 11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139517

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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