Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder

Bortolasci, Chiara, Voigt, C, Turner, Alyna, Mohebbi, Mohammadreza, Gray, Laura, Dodd, Seetal, Walder, Ken, Berk, Michael, Cotton, SM, Malhi, GS, Ng, CH, Dowling, N, Sarris, J and Dean, Olivia 2020, Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder, Acta Neuropsychiatrica, vol. 32, no. 6, pp. 313-320, doi: 10.1017/neu.2020.25.

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Title Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder
Author(s) Bortolasci, ChiaraORCID iD for Bortolasci, Chiara orcid.org/0000-0002-0794-6363
Voigt, C
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211
Gray, LauraORCID iD for Gray, Laura orcid.org/0000-0002-7903-5796
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Walder, KenORCID iD for Walder, Ken orcid.org/0000-0002-6758-4763
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Cotton, SM
Malhi, GS
Ng, CH
Dowling, N
Sarris, J
Dean, OliviaORCID iD for Dean, Olivia orcid.org/0000-0002-2776-3935
Journal name Acta Neuropsychiatrica
Volume number 32
Issue number 6
Start page 313
End page 320
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2020
ISSN 0924-2708
1601-5215
Keyword(s) N-acetylcysteine
antioxidant
bipolar disorder
clinical trial
inflammation
Summary Abstract Objective: The aims of this study were to evaluate changes in inflammatory and oxidative stress levels following treatment with N-acetylcysteine (NAC) or mitochondrial-enhancing agents (CT), and to assess the how these changes may predict and/or moderate clinical outcomes primarily the Montgomery-Åsberg Depression Rating Scale (MADRS). Methods: This study involved secondary analysis of a placebo-controlled randomised trial (n = 163). Serum samples were collected at baseline and week 16 of the clinical trial to determine changes in Interleukin-6 (IL-6) and total antioxidant capacity (TAC) following adjunctive CT and/or NAC treatment, and to explore the predictability of the outcome or moderator effects of these markers. Results: In the NAC-treated group, no difference was observed in serum IL-6 and TAC levels after 16 weeks of treatment with NAC or CT. However, results from a moderator analysis showed that in the CT group, lower IL-6 levels at baseline was a significant moderator of MADRS χ2 (df) = 4.90, p = 0.027) and Clinical Global Impression-Improvement (CGI-I, χ2 (df) = 6.28 p = 0.012). In addition, IL-6 was a non-specific but significant predictor of functioning (based on the Social and Occupational Functioning Assessment Scale (SOFAS)), indicating that individuals with higher IL-6 levels at baseline had a greater improvement on SOFAS regardless of their treatment (p = 0.023). Conclusion: Participants with lower IL-6 levels at baseline had a better response to the adjunctive treatment with the mitochondrial-enhancing agents in terms of improvements in MADRS and CGI-I outcomes.
Language eng
DOI 10.1017/neu.2020.25
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139632

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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