Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder Bortolasci, Chiara, Voigt, C, Turner, Alyna, Mohebbi, Mohammadreza, Gray, Laura, Dodd, Seetal, Walder, Ken, Berk, Michael, Cotton, SM, Malhi, GS, Ng, CH, Dowling, N, Sarris, J and Dean, Olivia 2020, Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder, Acta Neuropsychiatrica, vol. 32, no. 6, pp. 313-320, doi: 10.1017/neu.2020.25. Attached Files Name Description MIMEType Size Downloads Title Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder Author(s) Bortolasci, Chiara orcid.org/0000-0002-0794-6363 Voigt, C Turner, Alyna orcid.org/0000-0001-7389-2546 Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211 Gray, Laura orcid.org/0000-0002-7903-5796 Dodd, Seetal orcid.org/0000-0002-7918-4636 Walder, Ken orcid.org/0000-0002-6758-4763 Berk, Michael orcid.org/0000-0002-5554-6946 Cotton, SM Malhi, GS Ng, CH Dowling, N Sarris, J Dean, Olivia orcid.org/0000-0002-2776-3935 Journal name Acta Neuropsychiatrica Volume number 32 Issue number 6 Start page 313 End page 320 Total pages 8 Publisher Cambridge University Press Place of publication Cambridge, Eng. Publication date 2020 ISSN 0924-2708 1601-5215 Keyword(s) N-acetylcysteine antioxidant bipolar disorder clinical trial inflammation Summary Abstract Objective: The aims of this study were to evaluate changes in inflammatory and oxidative stress levels following treatment with N-acetylcysteine (NAC) or mitochondrial-enhancing agents (CT), and to assess the how these changes may predict and/or moderate clinical outcomes primarily the Montgomery-Åsberg Depression Rating Scale (MADRS). Methods: This study involved secondary analysis of a placebo-controlled randomised trial (n = 163). Serum samples were collected at baseline and week 16 of the clinical trial to determine changes in Interleukin-6 (IL-6) and total antioxidant capacity (TAC) following adjunctive CT and/or NAC treatment, and to explore the predictability of the outcome or moderator effects of these markers. Results: In the NAC-treated group, no difference was observed in serum IL-6 and TAC levels after 16 weeks of treatment with NAC or CT. However, results from a moderator analysis showed that in the CT group, lower IL-6 levels at baseline was a significant moderator of MADRS χ2 (df) = 4.90, p = 0.027) and Clinical Global Impression-Improvement (CGI-I, χ2 (df) = 6.28 p = 0.012). In addition, IL-6 was a non-specific but significant predictor of functioning (based on the Social and Occupational Functioning Assessment Scale (SOFAS)), indicating that individuals with higher IL-6 levels at baseline had a greater improvement on SOFAS regardless of their treatment (p = 0.023). Conclusion: Participants with lower IL-6 levels at baseline had a better response to the adjunctive treatment with the mitochondrial-enhancing agents in terms of improvements in MADRS and CGI-I outcomes. Language eng DOI 10.1017/neu.2020.25 Indigenous content off Field of Research 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30139632 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 03 Jul 2020, 12:21:39 EST Sat, 04 Jul 2020, 05:00:51 EST Sat, 26 Sep 2020, 02:31:49 EST Tue, 12 Jan 2021, 05:08:15 EST Wed, 20 Jan 2021, 14:45:00 EST Wed, 20 Jan 2021, 14:47:56 EST Wed, 20 Jan 2021, 14:51:17 EST Thu, 21 Jan 2021, 07:12:56 EST Sat, 06 Mar 2021, 01:30:17 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 224 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Fri, 03 Jul 2020, 12:21:39 EST