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Associations of vitamin D with inter- and intra-muscular adipose tissue and insulin resistance in women with and without polycystic ovary syndrome

Scott, D, Joham, A, Teede, H, Gibson-Helm, M, Harrison, C, Cassar, S, Hutchison, S, Ebeling, PR, Stepto, N and de Courten, B 2016, Associations of vitamin D with inter- and intra-muscular adipose tissue and insulin resistance in women with and without polycystic ovary syndrome, Nutrients, vol. 8, no. 12, pp. 1-10, doi: 10.3390/nu8120774.

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Title Associations of vitamin D with inter- and intra-muscular adipose tissue and insulin resistance in women with and without polycystic ovary syndrome
Author(s) Scott, DORCID iD for Scott, D orcid.org/0000-0001-5226-1972
Joham, A
Teede, H
Gibson-Helm, M
Harrison, C
Cassar, S
Hutchison, S
Ebeling, PR
Stepto, N
de Courten, B
Journal name Nutrients
Volume number 8
Issue number 12
Article ID 774
Start page 1
End page 10
Total pages 10
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2016-11-30
ISSN 2072-6643
Keyword(s) polycystic ovary syndrome
insulin resistance
intramuscular adipose tissue
vitamin D
exercise
obesity
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
SKELETAL-MUSCLE
BODY-COMPOSITION
OLDER-ADULTS
CARDIOVASCULAR-DISEASE
PHYSICAL-ACTIVITY
OBESE WOMEN
OVERWEIGHT
PCOS
FAT
Summary Low vitamin D and insulin resistance are common in polycystic ovary syndrome (PCOS) and associated with higher inter- and intra-muscular adipose tissue (IMAT). We investigated associations between vitamin D, IMAT and insulin resistance in a cross-sectional study of 40 women with PCOS and 30 women without PCOS, and pre- and post-exercise in a 12-week intervention in 16 overweight participants (10 with PCOS and six without PCOS). A non-classical body mass index (BMI) threshold was used to differentiate lean and overweight women (BMI ≥ 27 kg/m2). Measurements included plasma 25-hydroxyvitamin D (25OHD), insulin resistance (glucose infusion rate (GIR; mg/m2/min), fasting glucose and insulin, and glycated haemoglobin), visceral fat, mid-thigh IMAT (computed tomography) and total body fat (dual-energy X-ray absorptiometry). Women with both PCOS and low 25OHD levels had the lowest GIR (all p < 0.05). Higher IMAT was associated with lower 25OHD (B = -3.95; 95% CI -6.86, -1.05) and GIR (B = -21.3; 95% CI -37.16, -5.44) in women with PCOS. Overweight women with pre-exercise 25OHD ≥30 nmol/L had significant increases in GIR, and decreases in total and visceral fat (all p < 0.044), but no associations were observed when stratified by PCOS status. Women with PCOS and low 25OHD levels have increased insulin resistance which may be partly explained by higher IMAT. Higher pre-training 25OHD levels may enhance exercise-induced changes in body composition and insulin resistance in overweight women.
Language eng
DOI 10.3390/nu8120774
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, the authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139961

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.