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Effects of Vitamin D supplementation on inflammatory markers in heart failure: A systematic review and meta-analysis of randomized controlled trials

Rodriguez, AJ, Mousa, A, Ebeling, PR, Scott, D and De Courten, B 2018, Effects of Vitamin D supplementation on inflammatory markers in heart failure: A systematic review and meta-analysis of randomized controlled trials, Scientific Reports, vol. 8, no. 1, pp. 1-8, doi: 10.1038/s41598-018-19708-0.

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Title Effects of Vitamin D supplementation on inflammatory markers in heart failure: A systematic review and meta-analysis of randomized controlled trials
Author(s) Rodriguez, AJ
Mousa, A
Ebeling, PR
Scott, DORCID iD for Scott, D orcid.org/0000-0001-5226-1972
De Courten, B
Journal name Scientific Reports
Volume number 8
Issue number 1
Article ID 1169
Start page 1
End page 8
Total pages 8
Publisher Nature Research
Place of publication Berlin, Germany
Publication date 2018-01-18
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PLACEBO-CONTROLLED TRIAL
QUALITY-OF-LIFE
MICRONUTRIENT SUPPLEMENTATION
EXPRESSION
CYTOKINES
HEALTH
BIAS
Summary Vitamin D is reported to have anti-inflammatory properties; however the effects of vitamin D supplementation on inflammation in patients with heart failure (HF) have not been established. We performed a systematic review and meta-analysis examining effects of vitamin D supplementation on inflammatory markers in patients with HF. MEDLINE, CINAHL, EMBASE, All EBM, and Clinical Trials registries were systematically searched for RCTs from inception to 25 January 2017. Two independent reviewers screened all full text articles (no date or language limits) for RCTs reporting effects of vitamin D supplementation (any form, route, duration, and co-supplementation) compared with placebo or usual care on inflammatory markers in patients with heart failure. Two reviewers assessed risk of bias and quality using the grading of recommendations, assessment, development, and evaluation approach. Seven studies met inclusion criteria and six had data available for pooling (n = 1012). In meta-analyses, vitamin D-supplemented groups had lower concentrations of tumor necrosis factor-alpha (TNF-α) at follow-up compared with controls (n = 380; p = 0.04). There were no differences in C-reactive protein (n = 231), interleukin (IL)-10 (n = 247) or IL-6 (n = 154) between vitamin D and control groups (all p > 0.05). Our findings suggest that vitamin D supplementation may have specific, but modest effects on inflammatory markers in HF.
Language eng
DOI 10.1038/s41598-018-19708-0
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139965

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.