Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study

Kessing, LV, Rytgaard, HC, Ekstrøm, CT, Torp-Pedersen, C, Berk, Michael and Gerds, TA 2020, Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study, Hypertension, vol. 76, no. 4, pp. 1-17, doi: 10.1161/hypertensionaha.120.15605.

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Title Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study
Author(s) Kessing, LV
Rytgaard, HC
Ekstrøm, CT
Torp-Pedersen, C
Berk, MichaelORCID iD for Berk, Michael
Gerds, TA
Journal name Hypertension
Volume number 76
Issue number 4
Start page 1
End page 17
Total pages 17
Publisher American Heart Association
Place of publication Dallas, Tex.
Publication date 2020-10
ISSN 0194-911X
Keyword(s) antihypertensive agents
anxiety disorders
depressive disorder
Summary Hypertension, cardiovascular diseases, and cerebrovascular diseases are associated with an increased risk of depression, but it remains unclear whether treatment with antihypertensive agents decreases or increases this risk. The effects of individual drugs are also unknown. We used Danish population-based registers to systematically investigate whether the 41 most used individual antihypertensive drugs were associated with an altered risk of incident depression. Analyses of diuretics were included for comparisons. Participants were included in the study in January 2005 and followed until December 2015. Two different outcome measures were included: (1) a diagnosis of depressive disorder at a psychiatric hospital as an inpatient or outpatient and (2) a combined measure of a diagnosis of depression or use of antidepressants. Continued use of classes of angiotensin agents, calcium antagonists, and β-blockers was associated with significantly decreased rates of depression, whereas diuretic use was not. Individual drugs associated with decreased depression included 2 of 16 angiotensin agents: enalapril and ramipril; 3 of 10 calcium antagonists: amlodipine, verapamil, and verapamil combinations; and 4 of 15 β-blockers: propranolol, atenolol, bisoprolol, and carvedilol. No drug was associated with an increased risk of depression. In conclusion, real-life population-based data suggest a positive effect of continued use of 9 individual antihypertensive agents. This evidence should be used in guiding prescriptions for patients at risk of developing depression including those with prior depression or anxiety and patients with a family history of depression.
Language eng
DOI 10.1161/hypertensionaha.120.15605
Field of Research 1102 Cardiorespiratory Medicine and Haematology
1103 Clinical Sciences
1117 Public Health and Health Services
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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