Developmental strategies of curcumin solid dispersions for enhancing bioavailability

Tran, Ha Lien Phuong and Tran, TTD 2020, Developmental strategies of curcumin solid dispersions for enhancing bioavailability, Anti-Cancer Agents in Medicinal Chemistry, vol. 20, no. 16, pp. 1874-1882, doi: 10.2174/1871520620666200708103845.

Title Developmental strategies of curcumin solid dispersions for enhancing bioavailability
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong
Tran, TTD
Journal name Anti-Cancer Agents in Medicinal Chemistry
Volume number 20
Issue number 16
Start page 1874
End page 1882
Total pages 9
Publisher Bentham Science Publishers Ltd.
Place of publication San Francisco, Calif.
Publication date 2020
ISSN 1871-5206
Keyword(s) Solid dispersion
chemical stability
drug delivery
poorly water-soluble drug
Summary Background:Although curcumin has been demonstrated to be beneficial in treating various diseases,its low solubility, chemical stability and bioavailability limit its application, especially in cancer therapy.Methods:Solid dispersions have been utilized in the last few decades to improve the bioavailability and stabilityof curcumin.Results:However, there is a lack of summaries and classifications of the methods for preparing curcumin withthis technology. The current review aims to overview the strategies used to develop solid dispersions containingcurcumin for improving drug delivery. The classification of techniques for creating solid dispersions for curcuminwas summarized, including systems for protecting curcumin degradation despite its chemical stability. Theapplications of advanced nanotechnologies in recent studies of solid dispersions were also discussed to explainthe roles of nanoparticles in formulations.Conclusion:This overview of recent developments in formulating solid dispersions for improving curcuminbioavailability will contribute to future studies of curcumin for clinical development.
Language eng
DOI 10.2174/1871520620666200708103845
Indigenous content off
Field of Research 0304 Medicinal and Biomolecular Chemistry
1112 Oncology and Carcinogenesis
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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