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Insoluble polymers in solid dispersions for improving bioavailability of poorly water-soluble drugs

Tran, Thao TD and Tran, Phuong Ha Lien 2020, Insoluble polymers in solid dispersions for improving bioavailability of poorly water-soluble drugs, Polymers, vol. 12, no. 8, pp. 1-13, doi: 10.3390/POLYM12081679.

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Title Insoluble polymers in solid dispersions for improving bioavailability of poorly water-soluble drugs
Author(s) Tran, Thao TD
Tran, Phuong Ha LienORCID iD for Tran, Phuong Ha Lien orcid.org/0000-0001-8463-7516
Journal name Polymers
Volume number 12
Issue number 8
Article ID 1679
Start page 1
End page 13
Total pages 13
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2020-08
ISSN 2073-4360
2073-4360
Keyword(s) controlled release
dissolution enhancement
insoluble carrier
nano-sized solid dispersion
solid dispersion
Summary In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.
Language eng
DOI 10.3390/POLYM12081679
Indigenous content off
Field of Research 03 Chemical Sciences
09 Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30141732

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.