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Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Tiego, J, Chamberlain, SR, Harrison, BJ, Dawson, A, Albertella, L, Youssef, GJ, Fontenelle, LF and Yücel, M 2020, Heritability of overlapping impulsivity and compulsivity dimensional phenotypes, Scientific Reports, vol. 10, no. 1, pp. 1-17, doi: 10.1038/s41598-020-71013-x.

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Title Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
Author(s) Tiego, J
Chamberlain, SR
Harrison, BJ
Dawson, A
Albertella, L
Youssef, GJORCID iD for Youssef, GJ orcid.org/0000-0002-6178-4895
Fontenelle, LF
Yücel, M
Journal name Scientific Reports
Volume number 10
Issue number 1
Article ID 14378
Start page 1
End page 17
Total pages 17
Publisher Springer Science and Business Media LLC
Place of publication Berlin, Germany
Publication date 2020-09-01
ISSN 2045-2322
2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
GENOME-WIDE ASSOCIATION
ITEM RESPONSE THEORY
BEHAVIORAL DISINHIBITION
ENVIRONMENTAL-INFLUENCES
PSYCHOMETRIC VALIDATION
HIERARCHICAL TAXONOMY
ENDOPHENOTYPE CONCEPT
SPECTRUM DISORDERS
MEASUREMENT ISSUES
ANXIETY DISORDER
Summary Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.
Language eng
DOI 10.1038/s41598-020-71013-x
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30142408

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.