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Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

Chen, J, Wang, J, Deng, Y, Wang, T, Miao, T, Li, C, Cai, X, Liu, Y, Henri, Justin and Chen, L 2020, Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway, Bioinorganic Chemistry and Applications, vol. 2020, pp. 1-16, doi: 10.1155/2020/8890950.

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Title Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway
Author(s) Chen, J
Wang, J
Deng, Y
Wang, T
Miao, T
Li, C
Cai, X
Liu, Y
Henri, Justin
Chen, L
Journal name Bioinorganic Chemistry and Applications
Volume number 2020
Article ID 8890950
Start page 1
End page 16
Total pages 16
Publisher Hindawi
Place of publication Cairo, Egypt
Publication date 2020
ISSN 1565-3633
1687-479X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry
CYTOTOXICITY IN-VITRO
CELLULAR UPTAKE
DNA-BINDING
RUTHENIUM(II) COMPLEXES
CYCLE ARREST
ANTHRAQUINONE COMPLEXES
POLYPYRIDYL COMPLEXES
ANTICANCER PROPERTIES
ARENE COMPLEXES
SALICYLIC-ACID
Summary Two new Ru(II) complexes containing O, O-chelated ligands, Ru(dip)2(SA) (Ru-1) and Ru(dmp)2(SA) (Ru-2) (dip = 4,7-diphenyl-1,10-phenanthroline; dmp = 2,9-dimethyl-1,10-phenanthroline; SA = salicylate) were synthesized to evaluate their cytotoxicity in vitro. These complexes were found to exhibit moderate antitumor activity to different types of human cancers, including A549 (human lung carcinoma), MCF-7 (breast cancer), HeLa (human cervical cancer), and HepG2 (human hepatocellular carcinoma) cell lines, but displayed low toxicity to human normal cell lines BEAS-2B (immortalized human bronchial epithelial cells) when compared with that of cisplatin. Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/Bad ratio, enhancing cellular reactive oxygen species (ROS) accumulation, triggering DNA damage, decreasing mitochondrial membrane potential (MMP), and leading cytochrome c release from mitochondria. Notably, complex Ru-1 showed low toxicity to developing zebrafish embryos. The obtained results suggest that these new synthetic complexes have the potential to be developed as low-toxicity agents for lung cancer treatment.
Language eng
DOI 10.1155/2020/8890950
Indigenous content off
Field of Research 0302 Inorganic Chemistry
0399 Other Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30143080

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.