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Total Antioxidant Capacity and Frailty in Older Men

Tembo, Monica Chimwemwe, Holloway-Kew, KL, Bortolasci, Chiara, Sui, Sophia, Brennan-Olsen, Sharon, Williams, Lana, Kotowicz, Mark and Pasco, Julie 2020, Total Antioxidant Capacity and Frailty in Older Men, American Journal of Men's Health, September - October, pp. 1-6, doi: 10.1177/1557988320946592.

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Title Total Antioxidant Capacity and Frailty in Older Men
Author(s) Tembo, Monica ChimwemweORCID iD for Tembo, Monica Chimwemwe
Holloway-Kew, KL
Bortolasci, ChiaraORCID iD for Bortolasci, Chiara
Sui, SophiaORCID iD for Sui, Sophia
Brennan-Olsen, SharonORCID iD for Brennan-Olsen, Sharon
Williams, LanaORCID iD for Williams, Lana
Kotowicz, MarkORCID iD for Kotowicz, Mark
Pasco, JulieORCID iD for Pasco, Julie
Journal name American Journal of Men's Health
Season September - October
Start page 1
End page 6
Total pages 6
Publisher Sage
Place of publication London, Eng.
Publication date 2020
ISSN 1557-9883
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Public, Environmental & Occupational Health
Total antioxidant capacity
oxidative stress
Summary Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60–90 years) enrolled in the Geelong Osteoporosis Study. Frailty comprised at least three of unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. Serum TAC was measured by quantitative colorimetric determination and expressed as uric acid equivalents (mM). Relationships between TAC (in SD units) and frailty were explored using multivariable logistic regression models. Sociodemographic, anthropometric, and lifestyle variables were tested as potential confounders and effect modifiers. A sensitivity analysis excluded participants ( n = 145) in the upper quartile of TAC, who were likely to have hyperuricemia. Fifty (8.6%) men were frail. There was evidence that higher TAC levels were associated with increased likelihood of frailty ( OR 1.34, 95% confidence interval [CI; 0.99, 1.80]), and this was attenuated after adjustment for age and body mass index (BMI; OR 1.26, 95% CI [0.93,1.71]). No effect modifiers or other confounders were identified. The sensitivity analysis revealed a positive association between TAC and frailty, before and after accounting for age and BMI (adjusted OR 1.79, 95% CI [1.01, 3.17] p = .038). These results suggest a positive association between TAC levels and frailty, supporting the hypothesis that this biomarker could be useful in identifying individuals at risk of frailty. We speculate that a milieu of heightened oxidative stress in frailty may elevate the oxidative stress regulatory set point, raising antioxidant activity. This warrants further investigation.
Language eng
DOI 10.1177/1557988320946592
Indigenous content off
Field of Research 1117 Public Health and Health Services
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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