Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon

Tran, Ha Lien Phuong and Tran, Thao T.D. 2021, Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon, Current Pharmaceutical Design, vol. 27, no. 4, doi: 10.2174/1381612826666200917143816.

Title Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong
Tran, Thao T.D.
Journal name Current Pharmaceutical Design
Volume number 27
Issue number 4
Publisher Bentham Science Publishers Ltd.
Place of publication Schiphol, The Netherlands
Publication date 2021
ISSN 1381-6128
Keyword(s) colonic delivery
controlled release
mucoadhesive drug delivery system
mucoadhesive nanoparticles
Summary :Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantagesover existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. Thecontrolled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigatingmucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studiedwith promising applications. This review will provide an overview of and discuss specific strategies for developingmucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices,cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basicprinciple of these designs and advanced formulations throughout will lead to the development of products with efficientdrug delivery at the colon for therapies for different diseases.
Language eng
DOI 10.2174/1381612826666200917143816
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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