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Cytotoxic T cells swarm by homotypic chemokine signalling

Niño, JLG, Pageon, SV, Tay, SS, Colakoglu, F, Kempe, D, Hywood, J, Mazalo, JK, Cremasco, J, Govendir, MA, Dagley, LF, Hsu, K, Rizzetto, S, Zieba, J, Rice, G, Prior, V, O’neill, G, Williams, Richard J, Nisbet, DR, Kramer, B, Webb, AI, Luciani, F, Read, MN and Biro, M 2020, Cytotoxic T cells swarm by homotypic chemokine signalling, eLife, vol. 9, pp. 1-40, doi: 10.7554/eLife.56554.

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Title Cytotoxic T cells swarm by homotypic chemokine signalling
Author(s) Niño, JLG
Pageon, SV
Tay, SS
Colakoglu, F
Kempe, D
Hywood, J
Mazalo, JK
Cremasco, J
Govendir, MA
Dagley, LF
Hsu, K
Rizzetto, S
Zieba, J
Rice, G
Prior, V
O’neill, G
Williams, Richard JORCID iD for Williams, Richard J orcid.org/0000-0003-3831-8738
Nisbet, DR
Kramer, B
Webb, AI
Luciani, F
Read, MN
Biro, M
Journal name eLife
Volume number 9
Article ID e56554
Start page 1
End page 40
Total pages 40
Publisher eLife Sciences Publications
Place of publication Cambridge, Eng.
Publication date 2020-10-13
ISSN 2050-084X
2050-084X
Keyword(s) T cells
cell migration
chemotaxis
computational biology
emergent behaviour
human
immunology
inflammation
mouse
simulations
swarming
systems biology
Summary Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen receptor (CAR) T cells similarly employ intra-population signalling to drive rapid convergence. Thus, CTLs recognising a cognate target can induce a localised mass response by amplifying the direct recruitment of additional T cells independently of other leukocytes.
Language eng
DOI 10.7554/eLife.56554
Indigenous content off
Field of Research 0601 Biochemistry and Cell Biology
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144084

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.