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Long-term effectiveness of a lifestyle intervention on the prevention of type 2 diabetes in a middle-income country

Lotfaliany, M, Mansournia, MA, Azizi, F, Hadaegh, F, Zafari, N, Ghanbarian, A, Mirmiran, P, Oldenburg, B and Khalili, D 2020, Long-term effectiveness of a lifestyle intervention on the prevention of type 2 diabetes in a middle-income country, Scientific Reports, vol. 10, no. 1, pp. 1-10, doi: 10.1038/s41598-020-71119-2.

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Title Long-term effectiveness of a lifestyle intervention on the prevention of type 2 diabetes in a middle-income country
Author(s) Lotfaliany, MORCID iD for Lotfaliany, M orcid.org/0000-0001-6594-9004
Mansournia, MA
Azizi, F
Hadaegh, F
Zafari, N
Ghanbarian, A
Mirmiran, P
Oldenburg, B
Khalili, D
Journal name Scientific Reports
Volume number 10
Issue number 1
Article ID 14173
Start page 1
End page 10
Total pages 10
Publisher Nature Research
Place of publication Berlin, Germany
Publication date 2020-08-25
ISSN 2045-2322
2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CORONARY-HEART-DISEASE
CARDIOVASCULAR-DISEASE
HEALTH-PROMOTION
RISK-FACTORS
MULTIPLE IMPUTATION
TEHRANIAN ADULTS
COMMUNITY
PROGRAM
ADOLESCENTS
POPULATION
Summary This study aims to assess the effects of a community-based lifestyle intervention program on the incidence of type 2 diabetes (T2D). For this purpose, three communities in Tehran were chosen; one community received a face-to-face educational session embedded in a long-term community-wide lifestyle intervention aimed at supporting lifestyle changes. We followed up 9,204 participants (control: 5,739, intervention: 3,465) triennially from 1999 to 2015 (Waves 1–5). After a median follow-up of 3.5 years (wave 2), the risk of T2D was 30% lower in the intervention community as compared with two control communities by (Hazard-ratio: 0.70 [95% CI 0.53; 0.91]); however, the difference was not statistically significant in the following waves. After a median follow-up of 11.9 years (wave 5), there was a non-significant 6% reduction in the incidence of T2D in the intervention group as compared to the control group (Hazard-ratio: 0.94 [0.81, 1.08]). Moreover, after 11.9 years of follow-up, the intervention significantly improved the diet quality measured by the Dietary Approaches to Stop Hypertension concordance (DASH) score. Mean difference in DASH score in the intervention group versus control group was 0.2 [95% CI 0.1; 0.3]. In conclusion, the intervention prevented T2D by 30% in the short-term (3.5 years) but not long-term; however, effects on improvement of the diet maintained in the long-term.Registration: This study is registered at IRCT, a WHO primary registry (https://irct.ir). The registration date 39 is 2008-10-29 and the IRCT registration number is IRCT138705301058N1.
Language eng
DOI 10.1038/s41598-020-71119-2
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144095

Document type: Journal Article
Collections: Faculty of Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.