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Prevalence of normal weight obesity and its associated cardio-metabolic risk factors – Results from the baseline data of the Kerala Diabetes Prevention Program (KDPP)

Kapoor, N, Lotfaliany Abrand Abadi, Mojtaba, Sathish, T, Thankappan, KR, Thomas, N, Furler, J, Oldenburg, B and Tapp, RJ 2020, Prevalence of normal weight obesity and its associated cardio-metabolic risk factors – Results from the baseline data of the Kerala Diabetes Prevention Program (KDPP), PLoS ONE, vol. 15, no. 8, pp. 1-11, doi: 10.1371/journal.pone.0237974.

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Title Prevalence of normal weight obesity and its associated cardio-metabolic risk factors – Results from the baseline data of the Kerala Diabetes Prevention Program (KDPP)
Author(s) Kapoor, N
Lotfaliany Abrand Abadi, MojtabaORCID iD for Lotfaliany Abrand Abadi, Mojtaba orcid.org/0000-0001-6594-9004
Sathish, T
Thankappan, KR
Thomas, N
Furler, J
Oldenburg, B
Tapp, RJ
Journal name PLoS ONE
Volume number 15
Issue number 8
Article ID e0237974
Start page 1
End page 11
Total pages 11
Publisher PLOS
Place of publication San Francisco, CA
Publication date 2020-08-25
ISSN 1932-6203
1932-6203
Keyword(s) obesity
body weight
adipose tissue
diabetes mellitus
body mass index
blood plasma
type 2 diabetes risk
medical risk factors
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
INSULIN-RESISTANCE
BODY-COMPOSITION
FAT
Summary Background: Cardiometabolic disorders are frequently observed among those who have obesity as measured by body mass index (BMI). However, there is limited data available on the cardiometabolic profile of those who are non-obese by BMI but with a high body fat percentage (BFP), a phenotype frequently observed in the Indian population. We examined the prevalence of individuals with normal weight obesity (NWO) and the cardiometabolic profile of NWO individuals at high risk for type 2 diabetes(T2D) in a south Asian population. Material and methods: In the Kerala Diabetes Prevention Program, individuals aged between 30 to 60 years were screened using the Indian Diabetes Risk Score(IDRS) in 60 rural communities in the Indian state of Kerala. We used data from the baseline survey of this trial for this analysis which included 1147 eligible high diabetes risk individuals(IDRS >60). NWO was defined as BMI within the normal range and a high BFP (as per Asia-pacific ethnicity based cut-off); Non-obese (NO) as normal BMI and BFP and overtly obese (OB) as BMI ≥25 kg/m2 irrespective of the BFP. Data on demographic, clinical and biochemical characteristics were collected using standardized questionnaires and protocols. Body fat percentage was assessed using TANITA body composition analyser (model SC330), based on bioelectrical impedance. Results: The mean age of participants was 47.3 ± 7.5 years and 46% were women. The proportion with NWO was 32% (n = 364; 95% CI: 29.1 to 34.5%), NO was 17% (n = 200) and OB was 51% (n = 583). Among those with NWO, 19.7% had T2D, compared to 18.7% of those who were OB (p value = 0.45) and 8% with NO (p value = 0.003). Among those with NWO, mean systolic and diastolic blood pressure were 129 ± 20; 78 ± 12 mmHg, compared to 127 ± 17; 78±11 mmHg among those with OB (p value = 0.12;0.94) and 120 ± 16; 71±10 mmHg among with NO (p value<0.001; 0.001), respectively. A similar pattern of association was observed for LDL cholesterol and triglycerides. After adjusting for other risk factors, the odds of having diabetes (OR:2.72[95% CI:1.46–5.08]) and dyslipidemia (2.37[1.55–3.64]) was significantly more in individuals with NWO as compared to non-obese individuals. Conclusions: Almost one-third of this South Asian population, at high risk for T2D, had normal weight obesity. The significantly higher cardiometabolic risk associated with increased adiposity even in lower BMI individuals has important implications for recognition in clinical practice.
Language eng
DOI 10.1371/journal.pone.0237974
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, Kapoor et al.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144104

Document type: Journal Article
Collections: Faculty of Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.