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Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Khalilidehkordi, E, Clarke, L, Arnett, S, Bukhari, W, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, MW, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AG, Marriott, MP, Parratt, J, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P and Broadley, SA 2020, Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation, Frontiers in Neurology, vol. 11, pp. 1-8, doi: 10.3389/fneur.2020.00537.

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Title Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation
Author(s) Khalilidehkordi, E
Clarke, L
Arnett, S
Bukhari, W
Jimenez Sanchez, S
O'Gorman, C
Sun, J
Prain, KM
Woodhall, M
Silvestrini, R
Bundell, CS
Abernethy, D
Bhuta, S
Blum, S
Boggild, M
Boundy, K
Brew, BJ
Brown, M
Brownlee, W
Butzkueven, H
Carroll, WM
Chen, C
Coulthard, A
Dale, RC
Das, C
Fabis-Pedrini, MJ
Fulcher, D
Gillis, D
Hawke, S
Heard, R
Henderson, APD
Heshmat, S
Hodgkinson, S
Kilpatrick, TJ
King, J
Kneebone, C
Kornberg, AJ
Lechner-Scott, J
Lin, MW
Lynch, C
Macdonell, RAL
Mason, DF
McCombe, PA
Pereira, J
Pollard, JD
Ramanathan, S
Reddel, SW
Shaw, CORCID iD for Shaw, C orcid.org/0000-0002-1966-5200
Spies, J
Stankovich, J
Sutton, I
Vucic, S
Walsh, M
Wong, RC
Yiu, EM
Barnett, MH
Kermode, AG
Marriott, MP
Parratt, J
Slee, M
Taylor, BV
Willoughby, E
Brilot, F
Vincent, A
Waters, P
Broadley, SA
Journal name Frontiers in Neurology
Volume number 11
Article ID 537
Start page 1
End page 8
Total pages 8
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2020-06-16
ISSN 1664-2295
1664-2295
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
neuromyelitis optica
multiple sclerosis
aquaporin
epidemiology
relapse
seasonality
NEUROMYELITIS-OPTICA
SPECTRUM DISORDER
Summary Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.
Language eng
DOI 10.3389/fneur.2020.00537
Indigenous content off
Field of Research 1103 Clinical Sciences
1109 Neurosciences
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, Khalilidehkordi, Clarke, Arnett, Bukhari, Jimenez Sanchez, O’Gorman, Sun, Prain, Woodhall, Silvestrini, Bundell, Abernethy, Bhuta, Blum, Boggild, Boundy, Brew, Brown, Brownlee, Butzkueven, Carroll, Chen, Coulthard, Dale, Das, Fabis-Pedrini, Fulcher, Gillis, Hawke, Heard, Henderson, Heshmat, Hodgkinson, Kilpatrick, King, Kneebone, Kornberg, Lechner-Scott, Lin, Lynch, Macdonell, Mason, McCombe, Pereira, Pollard, Ramanathan, Reddel, Shaw, Spies, Stankovich, Sutton, Vucic, Walsh, Wong, Yiu, Barnett, Kermode, Marriott, Parratt, Slee, Taylor, Willoughby, Brilot, Vincent, Waters and Broadley
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144295

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.