Fast-dissolving Solid Dispersions for the Controlled Release of Poorly Water-soluble Drugs

Tran, Ha Lien Phuong, Lee, B-J and Tran, TTD 2020, Fast-dissolving Solid Dispersions for the Controlled Release of Poorly Water-soluble Drugs, Current Pharmaceutical Design, doi: 10.2174/1381612826666201021125844.

Title Fast-dissolving Solid Dispersions for the Controlled Release of Poorly Water-soluble Drugs
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong
Lee, B-J
Tran, TTD
Journal name Current Pharmaceutical Design
Publisher Bentham Science Publishers Ltd.
Place of publication Schiphol, The Netherlands
Publication date 2020-10-21
ISSN 1381-6128
Keyword(s) controlled release
fast dissolving
oral delivery.
poorly water-soluble drugs
solid dispersion
Summary :Solid dispersions offer many advantages for oral drug delivery of poorly water-soluble drugs over other systems,including an increase in drug solubility and drug dissolution. The improvement of drug absorption and higher bioavailabilityof active pharmaceutical ingredients in the gastrointestinal tract have been reported in various studies. In certaincircumstances, a rapid pharmacological effect is required for patients. Fast-dissolving solid dispersions provide an idealformulation in such cases. This report will provide an overview of current studies on fast-dissolving solid dispersions,including not only solid dispersion powders with fast dissolution rates but also specific does forms for the controlled releaseof poorly water-soluble drugs. Specifically, the applications of fast-dissolving solid dispersions will be described in everyspecific case. Moreover, pharmaceutical approaches and the utilization of polymers will be summarized. The classificationand analysis of fast-dissolving solid dispersions could provide insight into strategies and potential applications in futuredrug delivery developments.
Notes In Press
Language eng
DOI 10.2174/1381612826666201021125844
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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