Openly accessible

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Li, S, Nguyen, TL, Wong, EM, Dugué, PA, Dite, GS, Armstrong, NJ, Craig, Jeffrey, Mather, KA, Sachdev, PS, Saffery, R, Sung, J, Tan, Q, Thalamuthu, A, Milne, RL, Giles, GG, Southey, MC and Hopper, JL 2020, Genetic and environmental causes of variation in epigenetic aging across the lifespan, Clinical Epigenetics, vol. 12, no. 1, pp. 1-12, doi: 10.1186/s13148-020-00950-1.

Attached Files
Name Description MIMEType Size Downloads

Title Genetic and environmental causes of variation in epigenetic aging across the lifespan
Author(s) Li, S
Nguyen, TL
Wong, EM
Dugué, PA
Dite, GS
Armstrong, NJ
Craig, JeffreyORCID iD for Craig, Jeffrey orcid.org/0000-0003-3979-7849
Mather, KA
Sachdev, PS
Saffery, R
Sung, J
Tan, Q
Thalamuthu, A
Milne, RL
Giles, GG
Southey, MC
Hopper, JL
Journal name Clinical Epigenetics
Volume number 12
Issue number 1
Article ID 158
Start page 1
End page 12
Total pages 12
Publisher Springer
Place of publication Berlin, Germany
Publication date 2020
ISSN 1868-7075
1868-7083
Keyword(s) Aging
Epigenetic aging
Biological age
Epigenetic clock
DNA methylation
Twin study
Summary BackgroundDNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation. However, these studies are not able to provide a comprehensive view of the causes of variation over the lifespan.ResultsIn order to investigate the genetic and environmental causes of DNAm age variation across the lifespan, we pooled genome-wide DNA methylation data for 4217 people aged 0–92 years from 1871 families. DNAm age was calculated using the Horvath epigenetic clock. We estimated familial correlations in DNAm age for monozygotic (MZ) twin, dizygotic (DZ) twin, sibling, parent–offspring, and spouse pairs by cohabitation status. Genetic and environmental variance components models were fitted and compared. We found that twin pair correlations were − 0.12 to 0.18 around birth, not different from zero (all P > 0.29). For all pairs of relatives, their correlations increased with time spent living together (all P < 0.02) at different rates (MZ > DZ and siblings > parent–offspring; P < 0.001) and decreased with time spent living apart (P = 0.02) at similar rates. These correlation patterns were best explained by cohabitation-dependent shared environmental factors, the effects of which were 1.41 (95% confidence interval [CI] 1.16 to 1.66) times greater for MZ pairs than for DZ and sibling pairs, and the latter were 2.03 (95% CI 1.13 to 9.47) times greater than for parent–offspring pairs. Genetic factors explained 13% (95% CI − 10 to 35%) of variation (P = 0.27). Similar results were found for another two epigenetic clocks, suggesting that our observations are robust to how DNAm age is measured. In addition, results for the other clocks were consistent with there also being a role for prenatal environmental factors in determining their variation.ConclusionsVariation in DNAm age is mostly caused by environmental factors, including those shared to different extents by relatives while living together and whose effects persist into old age. The equal environment assumption of the classic twin study might not hold for epigenetic aging.
Language eng
DOI 10.1186/s13148-020-00950-1
Indigenous content off
Field of Research 0604 Genetics
1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144693

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 3 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 71 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Fri, 30 Oct 2020, 07:09:54 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.