The effect of concomitant benzodiazepine use on neurocognition in stable, long-term patients with bipolar disorder

Cañada, Y, Sabater, A, Sierra, P, Balanzá-Martínez, V, Berk, Michael, Dodd, Seetal, Navalón, P, Livianos, L and García-Blanco, A 2020, The effect of concomitant benzodiazepine use on neurocognition in stable, long-term patients with bipolar disorder, Australian & New Zealand Journal of Psychiatry, pp. 1-12, doi: 10.1177/0004867420969819.

Attached Files
Name Description MIMEType Size Downloads

Title The effect of concomitant benzodiazepine use on neurocognition in stable, long-term patients with bipolar disorder
Author(s) Cañada, Y
Sabater, A
Sierra, P
Balanzá-Martínez, V
Berk, MichaelORCID iD for Berk, Michael
Dodd, SeetalORCID iD for Dodd, Seetal
Navalón, P
Livianos, L
García-Blanco, A
Journal name Australian & New Zealand Journal of Psychiatry
Start page 1
End page 12
Total pages 12
Publisher SAGE Publications
Place of publication London, Eng.
Publication date 2020-11-06
ISSN 0004-8674
Keyword(s) Bipolar disorder
cognitive impairment
Summary Objective: Neurocognitive dysfunction is a common feature of bipolar disorder even in euthymia, and psychopharmacological treatment could have an effect on cognition. Long-term prescription of benzodiazepines in bipolar disorder is a common practice, and their effect on neurocognition has not been well studied in this population. The aim of this study was to evaluate the impact of concomitant benzodiazepine long-term use on neurocognitive function in stable euthymic bipolar disorder patients. Methods: Seventy-three euthymic bipolar disorder outpatients and 40 healthy individuals were assessed using a neurocognitive battery. Patients were classified in two groups according to the presence of benzodiazepines in their treatment: the benzodiazepine group ( n = 34) and the non- benzodiazepine group ( n = 39). Neurocognitive performance was compared between the groups using a multivariate analysis of covariance, considering age, number of depressive episodes, adjuvant antipsychotic drugs, Young Mania Rating Scale score and Hamilton Depression Rating Scale score as covariates. Results: Both bipolar disorder groups (benzodiazepine and non-benzodiazepine) showed an impairment in memory domains (Immediate Visual Memory [ p = 0.013], Working Memory [ p < 0.001], and Letter-Number Sequence [ p < 0.001] from the Wechsler Memory Scale-Revised-III) and slower processing speed functions (Stroop Colour [ p < 0.001]) relative to the control group. Nevertheless, the benzodiazepine group showed a greater impairment in executive functions (Conceptual Level Responses [ p = 0.024] from the Wisconsin Card Sorting Test and Frontal Assessment Battery [ p = 0.042]). Conclusion: Although memory and processing speed impairments were found in bipolar disorder, regardless of their benzodiazepine treatment, benzodiazepine users presented additional neurocognitive impairments in terms of executive functioning. These findings support restricted prescription of benzodiazepines in individuals with bipolar disorder.
Notes In Press
Language eng
DOI 10.1177/0004867420969819
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 62 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 19 Nov 2020, 06:51:18 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact