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Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells

Ajji, Parminder K., Walder, Ken and Puri, Munish 2020, Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells, Frontiers in Pharmacology, vol. 11, pp. 1-13, doi: 10.3389/fphar.2020.574496.

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Title Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells
Author(s) Ajji, Parminder K.
Walder, KenORCID iD for Walder, Ken orcid.org/0000-0002-6758-4763
Puri, MunishORCID iD for Puri, Munish orcid.org/0000-0003-2469-3326
Journal name Frontiers in Pharmacology
Volume number 11
Article ID 574496
Start page 1
End page 13
Total pages 13
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2020-10-28
ISSN 1663-9812
1663-9812
Keyword(s) bioactives
naringenin
naringin
quercetin
ribosome inactivating proteins
therapeutics
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
RIBOSOME-INACTIVATING PROTEIN
ENDOPLASMIC-RETICULUM STRESS
NARINGIN SUPPRESSES
HUMAN PROSTATE
INHIBITION
PATHWAYS
PROLIFERATION
METABOLISM
ARREST
Summary Flavonoids such as naringenin, quercetin, and naringin are known to exhibit anticancer properties. In this study, we examined the effects of these flavonoids on cell viability and apoptotic pathways of cancer cells, either singly or in combination with the type 1 ribosome inactivating protein, Balsamin. Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes. Out of the three flavonoids tested, the Balsamin-Naringenin and Balsamin-Quercetin combinations appeared to be most effective compared to the Balsamin-Naringin combination. Balsamin combined with flavonoids also activated endoplasmic reticulum (ER)-stress–mediated apoptosis in breast cancer (MCF-7) cells, which was not activated by Balsamin treatment alone. These experimental results showed that Balsamin combined with flavonoids can reduce HepG2 and MCF-7 cells viability and induce apoptosis, which could be considered as a promising therapeutic approach to sensitize cells to Balsamin treatment, thereby improving its efficacy in breast or liver cancer therapy.
Language eng
DOI 10.3389/fphar.2020.574496
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, Ajji, Walder and Puri
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30145927

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.