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Telomere length and CCL11 levels are associated with gray matter volume and episodic memory performance in Schizophrenia: Evidence of pathological accelerated aging

Czepielewski, Leticia Sanguinetti, Massuda, Raffael, Panizzutti, Bruna, Grun, Lucas Kich, Barbé-Tuana, Florencia María, Teixeira, Antonio Lucio, Barch, Deanna M. and Gama, Clarissa S. 2018, Telomere length and CCL11 levels are associated with gray matter volume and episodic memory performance in Schizophrenia: Evidence of pathological accelerated aging, Schizophrenia Bulletin, vol. 44, no. 1, pp. 158-167, doi: 10.1093/schbul/sbx015.

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Title Telomere length and CCL11 levels are associated with gray matter volume and episodic memory performance in Schizophrenia: Evidence of pathological accelerated aging
Author(s) Czepielewski, Leticia Sanguinetti
Massuda, Raffael
Panizzutti, Bruna
Grun, Lucas Kich
Barbé-Tuana, Florencia María
Teixeira, Antonio Lucio
Barch, Deanna M.
Gama, Clarissa S.
Journal name Schizophrenia Bulletin
Volume number 44
Issue number 1
Start page 158
End page 167
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2018-01-01
ISSN 0586-7614
1745-1701
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
schizophrenia
pathological accelerated aging
biomarkers
episodic memory
gray matter volume
INCREASED SERUM-LEVELS
PSYCHIATRIC-DISORDERS
NEUROCOGNITIVE DEFICITS
INFLAMMATORY CYTOKINES
COGNITIVE PERFORMANCE
MENTAL-DISORDERS
BIPOLAR DISORDER
BRAIN
METAANALYSIS
HYPOTHESIS
Summary Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis. Comparisons of group means and correlations were performed. Participants with SZ had decreased TL and GM volume, increased CCL11, and worse memory performance compared to HC. In SZ, shorter TL was related to increased CCL11, and both biomarkers were related to reduced GM volume, all of which were related to worse memory performance. Older age was only associated with reduced GM, but longer duration of illness was related with all the aforementioned variables. Younger age of disease onset was associated with increased CCL11 levels and worse memory performance. In HC, there were no significant correlations except between memory and GM. Our results are consistent with the hypothesis of accelerated aging in SZ. These results may indicate that it is not age itself, but the impact of the disease associated with a pathological accelerated aging that leads to impaired outcomes in SZ.
Language eng
DOI 10.1093/schbul/sbx015
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146053

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.