Biodegradable metal-derived Magnesium and Sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation

Liu, Yang, Li, Huafang, Xu, Jiankun, TerBush, Jessica, Li, Wenting, Setty, Mohan, Guan, Shaokang, Nguyen, Thanh D., Qin, Ling and Zheng, Yufeng 2020, Biodegradable metal-derived Magnesium and Sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation, Chemical Engineering Journal, no. In-Press, doi: 10.1016/j.cej.2020.127616.

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Title Biodegradable metal-derived Magnesium and Sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation
Author(s) Liu, Yang
Li, Huafang
Xu, Jiankun
TerBush, Jessica
Li, Wenting
Setty, MohanORCID iD for Setty, Mohan orcid.org/0000-0003-1871-0249
Guan, Shaokang
Nguyen, Thanh D.
Qin, Ling
Zheng, Yufeng
Journal name Chemical Engineering Journal
Issue number In-Press
Article ID 127616
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2020-11-04
ISSN 1385-8947
Keyword(s) biodegradable metals
magnesium alloy
sodium
osteogenesis
calvarial defect
Summary Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better mechanical property and corrosion resistance due to the uniform distribution of Na in Mg2Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression in adipose derived stem cells in vitro. It significantly promoted the rat calvarial defect bone regeneration through osteogenesis and angiogenesis, attributed to the co-release of Na and Mg ions, by increasing the expression of calcitonin gene-related peptide, osteocalcin as well as vascular endothelial growth factor. The current study provided an innovative approach by using master alloy to incorporate essential elements (such as Na or K) for fabricating biodegradable Mg alloys with reduced galvanic corrosion and enhanced biological functions.
Language eng
DOI 10.1016/j.cej.2020.127616
Indigenous content off
Field of Research 0904 Chemical Engineering
0905 Civil Engineering
0907 Environmental Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID National Natural Science Foundation of China [Grants No. 51871004, 31700819 and 81802152]
NSFC/RGC Joint Research Scheme [Grant No. 5161101031]
Young Elite Scientists Sponsorship Program by CAST [YESS, Grant No.2018QNRC001]
Fundamental Research Funds for the Central Universities [Grant No. 06500098]
Hong Kong RGC Theme-based Research Scheme [Ref No. T13-402/17-N]
RGC Collaborative Research Fund [Ref No. C4026-17WF]
Copyright notice ©2020, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146143

Document type: Journal Article
Collections: Institute for Frontier Materials
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