Individual Differences in Intrinsic Brain Networks Predict Symptom Severity in Autism Spectrum Disorders

Pua, Emmanuel Peng Kiat, Thomson, Phoebe, Yang, Joseph Yuan-Mou, Craig, Jeffrey M., Ball, Gareth and Seal, Marc 2021, Individual Differences in Intrinsic Brain Networks Predict Symptom Severity in Autism Spectrum Disorders, Cerebral cortex, vol. 31, no. 1, pp. 681-693, doi: 10.1093/cercor/bhaa252.

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Title Individual Differences in Intrinsic Brain Networks Predict Symptom Severity in Autism Spectrum Disorders
Author(s) Pua, Emmanuel Peng Kiat
Thomson, Phoebe
Yang, Joseph Yuan-Mou
Craig, Jeffrey M.ORCID iD for Craig, Jeffrey M.
Ball, Gareth
Seal, Marc
Journal name Cerebral cortex
Volume number 31
Issue number 1
Start page 681
End page 693
Total pages 13
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021-01
ISSN 1047-3211
Keyword(s) autism spectrum disorders
intrinsic brain networks
neural correlates
Summary The neurobiology of heterogeneous neurodevelopmental disorders such as Autism Spectrum Disorders (ASD) is still unknown. We hypothesized that differences in subject-level properties of intrinsic brain networks were important features that could predict individual variation in ASD symptom severity. We matched cases and controls from a large multicohort ASD dataset (ABIDE-II) on age, sex, IQ, and image acquisition site. Subjects were matched at the individual level (rather than at group level) to improve homogeneity within matched case–control pairs (ASD: n = 100, mean age = 11.43 years, IQ = 110.58; controls: n = 100, mean age = 11.43 years, IQ = 110.70). Using task-free functional magnetic resonance imaging, we extracted intrinsic functional brain networks using projective non-negative matrix factorization. Intrapair differences in strength in subnetworks related to the salience network (SN) and the occipital-temporal face perception network were robustly associated with individual differences in social impairment severity (T = 2.206, P = 0.0301). Findings were further replicated and validated in an independent validation cohort of monozygotic twins (n = 12; 3 pairs concordant and 3 pairs discordant for ASD). Individual differences in the SN and face-perception network are centrally implicated in the neural mechanisms of social deficits related to ASD.
Language eng
DOI 10.1093/cercor/bhaa252
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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