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Inflammatory versus anti-inflammatory profiles in major depressive disorders—the role of il-17, il-21, il-23, il-35 and foxp3

Gałecka, M, Bliźniewska-Kowalska, K, Orzechowska, A, Szemraj, J, Maes, M, Berk, Michael, Su, KP and Gałecki, P 2021, Inflammatory versus anti-inflammatory profiles in major depressive disorders—the role of il-17, il-21, il-23, il-35 and foxp3, Journal of Personalized Medicine, vol. 11, no. 2, pp. 1-14, doi: 10.3390/jpm11020066.

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Title Inflammatory versus anti-inflammatory profiles in major depressive disorders—the role of il-17, il-21, il-23, il-35 and foxp3
Author(s) Gałecka, M
Bliźniewska-Kowalska, K
Orzechowska, A
Szemraj, J
Maes, M
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Su, KP
Gałecki, P
Journal name Journal of Personalized Medicine
Volume number 11
Issue number 2
Article ID 66
Start page 1
End page 14
Total pages 14
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021
ISSN 2075-4426
2075-4426
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Medicine, General & Internal
General & Internal Medicine
depression
MDD
autoimmunity
inflammation
interleukin 17 (IL-17)
interleukin 21 (IL-21)
interleukin 23 (IL-23)
interleukin 35 (IL-35)
Foxp3
psychiatry
mental disorders
neuroscience
Summary Background: The authors of this research study intended to verify whether there are any changes in gene expression in depressed patients without coexisting inflammatory diseases for selected immune-inflammatory factors that are particularly important in autoimmune disease pathogenesis (IL-17, IL-21, IL-23, IL-35, Foxp3). Methods: The study was carried out on a group of 190 patients with depression and 100 healthy volunteers. The severity of depressive symptoms was assessed using the Hamilton Depression Scale. RT-PCR was used to evaluate mRNA expression and ELISA was used to measure protein expression of these genes. Results: The level of gene expression for IL-17, IL-21, IL-23, and IL-35 was substantially higher in the group of patients with depression compared to the control group. The mean mRNA expression of Foxp3 was considerably reduced in patients suffering from depressive disorders. There was a statistically significant correlation between the number of hospitalizations and the expression of specific inflammatory factors. Conclusions: Expression of specific inflammatory genes may be a factor in the etiopathogenesis of depressive disorders. The duration of the disease seems to be more important for the expression of the genes in question than the severity of depression. These cytokines may affect the metabolism of neurotransmitters and neuroendocrine functions in the brain as well as be a marker and a new potential therapeutic target for recurrent depressive disorders.
Language eng
DOI 10.3390/jpm11020066
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30147658

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.