Openly accessible

Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study

Chandrasekaran, Vinoomika, Pasco, Julie A, Stuart, Amanda L, Brennan-Olsen, Sharon L, Berk, Michael, Hodge, Jason M, Samarasinghe, Rasika M and Williams, Lana J 2021, Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study, BMC musculoskeletal disorders, vol. 22, no. 1, pp. 1-7, doi: 10.1186/s12891-021-04042-w.

Attached Files
Name Description MIMEType Size Downloads

Title Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study
Author(s) Chandrasekaran, VinoomikaORCID iD for Chandrasekaran, Vinoomika orcid.org/0000-0002-3910-3248
Pasco, Julie AORCID iD for Pasco, Julie A orcid.org/0000-0002-8968-4714
Stuart, Amanda LORCID iD for Stuart, Amanda L orcid.org/0000-0001-8770-9511
Brennan-Olsen, Sharon LORCID iD for Brennan-Olsen, Sharon L orcid.org/0000-0003-3269-5401
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Hodge, Jason M
Samarasinghe, Rasika MORCID iD for Samarasinghe, Rasika M orcid.org/0000-0002-3669-0985
Williams, Lana JORCID iD for Williams, Lana J orcid.org/0000-0002-1377-1272
Journal name BMC musculoskeletal disorders
Volume number 22
Issue number 1
Article ID 172
Start page 1
End page 7
Total pages 7
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2021
ISSN 1471-2474
1471-2474
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Orthopedics
Rheumatology
Bone mineral density
Quantitative heel ultrasound
Anticonvulsants
Osteoporosis
psychiatry
neuroscience
medical comorbidity
Summary Background Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods Data from 926 men (24-73 yr) and 1070 women (21-94 yr) participating in the Geelong Osteoporosis Study were included. Bone mineral density (BMD, g/cm2) of the PA-spine and total hip was measured using dual-energy X-ray absorptiometry (Lunar). Bone quality was determined using quantitative heel ultrasound (QUS). Anthropometry was conducted and socioeconomic status was determined. Medication and lifestyle information was obtained via questionnaire. Linear regression was used to test associations between anticonvulsant use and bone health before and after adjustment for potential confounders. Results Seventeen (1.8%) men and 20 (1.9%) women reported anticonvulsant use. In men, anticonvulsant users had 9.1% lower adjusted mean BMD at the spine and hip compared to non-users. Body mass index was an effect modifier at the spine. Anticonvulsant users also had 1.8% lower speed of sound (SOS), 10.6% lower broadband ultrasound attenuation (BUA) and 13.7% lower stiffness index (SI) compared to non-users. In women, BMD tended to be lower at the hip compared to non-users as with the bone quality measure, BUA. No significant associations were observed at the spine or the other bone quality measures, SOS and SI. Conclusion Our data suggest that bone quantity and quality, assessed using BMD and QUS, are lower for men and possibly women who use anticonvulsants. While further exploration into potential mechanisms is needed, our findings suggest that monitoring bone health among users of anticonvulsants is warranted.
Language eng
DOI 10.1186/s12891-021-04042-w
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30148122

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 56 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 18 Feb 2021, 07:17:16 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.