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Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial

Hoang, Ngan TD, Orellana, Liliana, Gibson, Rosalind S, Le, Tuyen D, Worsley, Anthony, Sinclair, Andrew J, Hoang, Nghien TT and Szymlek-Gay, Ewa A 2021, Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial, Scientific reports, vol. 11, no. 1, pp. 1-13, doi: 10.1038/s41598-021-83129-9.

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Title Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
Author(s) Hoang, Ngan TD
Orellana, LilianaORCID iD for Orellana, Liliana orcid.org/0000-0003-3736-4337
Gibson, Rosalind S
Le, Tuyen D
Worsley, AnthonyORCID iD for Worsley, Anthony orcid.org/0000-0002-4635-6059
Sinclair, Andrew J
Hoang, Nghien TT
Szymlek-Gay, Ewa AORCID iD for Szymlek-Gay, Ewa A orcid.org/0000-0002-6533-7945
Journal name Scientific reports
Volume number 11
Issue number 1
Article ID 3728
Start page 1
End page 13
Total pages 13
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2021
ISSN 2045-2322
2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
anaemia
biomarkers
iron
malnutrition
nutritional supplements
obesity
paediatric research
Summary Abstract We aimed to determine the efficacy of multiple micronutrient supplementation on the biomarkers of iron, zinc, and vitamin A status across anthropometric status categories in Vietnamese school children. In this 22-week randomised controlled trial, 347 undernourished, normal weight, or overweight/obese children aged 6–9 years were allocated to receive every school day a multiple micronutrient supplement (10 mg iron, 10 mg zinc, 400 µg vitamin A) or a placebo. Haematological indices; circulating ferritin, zinc, and retinol (corrected for inflammation); and C-reactive protein were measured at baseline and 22 weeks. At week 22, linear mixed models showed that mean corpuscular volume increased by 0.3 fL, serum ferritin by 9.1 µg/L, plasma zinc by 0.9 µmol/L, and plasma retinol by 15%, and the prevalence of zinc deficiency decreased by 17.3% points in the intervention group compared to placebo. No intervention effects were found for other haematological indices, or the prevalence of anaemia. Multiple micronutrient supplementation for 22 weeks improved the biomarkers of zinc and vitamin A status and some biomarkers of iron status, and reduced the prevalence of zinc deficiency in Vietnamese school children. Trial registration: This trial was registered on 06/09/2016 at www.anzctr.org.au as ACTRN12616001245482.
Language eng
DOI 10.1038/s41598-021-83129-9
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30148145

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.