Risk factors for incident falls and fractures in older men with and without type 2 diabetes mellitus: The concord health and ageing in men project

Mesinovic, Jakub, Scott, David, Seibel, Markus J., Cumming, Robert G., Naganathan, Vasi, Blyth, Fiona M., Le Couteur, David G., Waite, Louise M., Handelsman, David J. and Hirani, Vasant 2021, Risk factors for incident falls and fractures in older men with and without type 2 diabetes mellitus: The concord health and ageing in men project, Journals of gerontology - Series A Biological sciences and medical sciences, vol. 76, no. 6, pp. 1090-1100, doi: 10.1093/gerona/glab062.

Attached Files
Name Description MIMEType Size Downloads

Title Risk factors for incident falls and fractures in older men with and without type 2 diabetes mellitus: The concord health and ageing in men project
Author(s) Mesinovic, Jakub
Scott, DavidORCID iD for Scott, David orcid.org/0000-0001-5226-1972
Seibel, Markus J.
Cumming, Robert G.
Naganathan, Vasi
Blyth, Fiona M.
Le Couteur, David G.
Waite, Louise M.
Handelsman, David J.
Hirani, Vasant
Journal name Journals of gerontology - Series A Biological sciences and medical sciences
Volume number 76
Issue number 6
Start page 1090
End page 1100
Total pages 11
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021-06
ISSN 1079-5006
1758-535X
Keyword(s) ASSOCIATION
Body composition
Bone
COGNITIVE DECLINE
COMPLICATIONS
CONTRAST SENSITIVITY
DEPRESSION
DISABILITY
Falls
FAT MASS
Fractures
Geriatrics & Gerontology
Gerontology
HIP-FRACTURES
Life Sciences & Biomedicine
PREDICTOR
Sarcopenia
Science & Technology
Type 2 diabetes
Summary Background
Type 2 diabetes mellitus (T2DM) increases falls and fracture risk. Our objective was to compare incidence and risk factors for falls and fractures in community-dwelling older men with and without T2DM.
Methods
A total of 1705 men (471 with T2DM; 1234 without T2DM) aged ≥70 years were assessed at baseline. Men were contacted every 4 months for 6.0 ± 2.2 years to ascertain incident falls and fractures, with the latter being confirmed by radiographic reports. Hip fractures were ascertained via data linkage (follow-up: 8.8 ± 3.6 years). Risk factors for falls and fractures included physical activity and function, body composition, medications, and vision measures.
Results
Men with T2DM had similar fall (incident rate ratio [IRR]: 0.92 [95% confidence interval {CI}: 0.70, 1.12], n = 1246) and fracture rates (hazard ratio [HR]: 0.86 [95% CI: 0.56, 1.32], n = 1326) compared to men without T2DM after adjustment for significant risk factors. In men with T2DM, depression (IRR: 1.87 [95% CI: 1.05, 3.34], n = 333), sulphonylurea usage (IRR: 2.07 [95% CI: 1.30, 3.27]) and a greater number of prescription medications (IRR: 1.13 [95% CI: 1.03, 1.24]) were independently associated with increased fall rates, and higher total hip bone mineral density was independently associated with lower fracture rates (HR: 0.63 [95% CI: 0.47, 0.86], n = 351). Interaction terms demonstrated that better contrast sensitivity was independently associated with lower fracture rates (HR: 0.14 [95% CI: 0.02, 0.87]) in men with T2DM compared to men without T2DM.
Conclusion
Fall and fracture rates were similar in men with and without T2DM after adjusting for significant risk factors. Vision assessments including contrast sensitivity measures may improve fracture prediction in older men with T2DM.
Language eng
DOI 10.1093/gerona/glab062
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149267

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 8 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 18 Mar 2021, 07:18:21 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.