Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health

Berding, K, Vlckova, K, Marx, Wolfgang, Schellekens, H, Stanton, C, Clarke, G, Jacka, Felice, Dinan, TG and Cryan, JF 2021, Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health, Advances in Nutrition, vol. 12, no. 4, pp. 1239-1285, doi: 10.1093/advances/nmaa181.

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Title Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Author(s) Berding, K
Vlckova, K
Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
Schellekens, H
Stanton, C
Clarke, G
Jacka, FeliceORCID iD for Jacka, Felice orcid.org/0000-0002-9825-0328
Dinan, TG
Cryan, JF
Journal name Advances in Nutrition
Volume number 12
Issue number 4
Start page 1239
End page 1285
Total pages 47
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021-07
ISSN 2161-8313
2156-5376
Keyword(s) diet
microbiota
brain
behavior
mental health
mechanisms
gut–brain axis
nutrition
Summary ABSTRACT Over the past decade, the gut microbiota has emerged as a key component in regulating brain processes and behavior. Diet is one of the major factors involved in shaping the gut microbiota composition across the lifespan. However, whether and how diet can affect the brain via its effects on the microbiota is only now beginning to receive attention. Several mechanisms for gut-to-brain communication have been identified, including microbial metabolites, immune, neuronal, and metabolic pathways, some of which could be prone to dietary modulation. Animal studies investigating the potential of nutritional interventions on the microbiota–gut–brain axis have led to advancements in our understanding of the role of diet in this bidirectional communication. In this review, we summarize the current state of the literature triangulating diet, microbiota, and host behavior/brain processes and discuss potential underlying mechanisms. Additionally, determinants of the responsiveness to a dietary intervention and evidence for the microbiota as an underlying modulator of the effect of diet on brain health are outlined. In particular, we emphasize the understudied use of whole-dietary approaches in this endeavor and the need for greater evidence from clinical populations. While promising results are reported, additional data, specifically from clinical cohorts, are required to provide evidence-based recommendations for the development of microbiota-targeted, whole-dietary strategies to improve brain and mental health.
Language eng
DOI 10.1093/advances/nmaa181
Field of Research 1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149309

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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