Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies potential targets of allele-specific immunity to clinical malaria

Shah, Z, Naung, MT, Moser, KA, Adams, M, Buchwald, AG, Dwivedi, A, Ouattara, A, Seydel, KB, Mathanga, DP, Barry, Alyssa, Serre, D, Laufer, MK, Silva, JC and Takala-Harrison, S 2020, Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies potential targets of allele-specific immunity to clinical malaria, medRxiv, pp. 1-36, doi: 10.1101/2020.09.16.20196253.

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Title Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies potential targets of allele-specific immunity to clinical malaria
Author(s) Shah, Z
Naung, MT
Moser, KA
Adams, M
Buchwald, AG
Dwivedi, A
Ouattara, A
Seydel, KB
Mathanga, DP
Barry, AlyssaORCID iD for Barry, Alyssa orcid.org/0000-0002-1189-2310
Serre, D
Laufer, MK
Silva, JC
Takala-Harrison, S
Journal name medRxiv
Start page 1
End page 36
Total pages 36
Publisher Cold Spring Harbor Laboratory
Publication date 2020-09-18
Summary Abstract Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. This immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode likely targets of naturally acquired immunity and that should be further characterized for their potential as vaccine candidates.
Language eng
DOI 10.1101/2020.09.16.20196253
Indigenous content off
Field of Research 110804 Medical Virology
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149570

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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