Openly accessible

Group phenotypic composition in cancer

Capp, Jean-Pascal, Degregori, James, Nedelcu, Aurora M, Dujon, Antoine M, Boutry, Justine, Pujol, Pascal, Alix-Panabières, Catherine, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Marusyk, Andriy, Gatenby, Robert and Thomas, Frederic 2021, Group phenotypic composition in cancer, eLife, vol. 10, pp. 1-20, doi: 10.7554/eLife.63518.

Attached Files
Name Description MIMEType Size Downloads

Title Group phenotypic composition in cancer
Author(s) Capp, Jean-Pascal
Degregori, James
Nedelcu, Aurora M
Dujon, Antoine M
Boutry, Justine
Pujol, Pascal
Alix-Panabières, Catherine
Hamede, Rodrigo
Roche, Benjamin
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Marusyk, Andriy
Gatenby, Robert
Thomas, Frederic
Journal name eLife
Volume number 10
Article ID e63518
Start page 1
End page 20
Total pages 20
Publisher eLife Sciences Publications
Place of publication Cambridge, Eng.
Publication date 2021-03
ISSN 2050-084X
2050-084X
Keyword(s) cancer biology
ecology
evolutionary biology
medicine
Summary Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups where fitness of the group cannot be reduced to the average fitness of individual group members. A growing body of studies reveals limitations of reductionist approaches to explaining biological and clinical observations. For example, induction of angiogenesis, inhibition of the immune system, and niche engineering through environmental acidification and/or remodeling of extracellular matrix cannot be achieved by single tumor cells and require collective actions of groups of cells. Success or failure of such group activities depends on the phenotypic makeup of the individual group members. Conversely, these group activities affect the fitness of individual members of the group, ultimately affecting the composition of the group. This phenomenon, where phenotypic makeup of individual group members impacts the fitness of both members and groups, has been captured in the term ‘group phenotypic composition’ (GPC). We provide examples where considerations of GPC could help in understanding the evolution and clinical progression of cancers and argue that use of the GPC framework can facilitate new insights into cancer biology and assist with the development of new therapeutic strategies.
Language eng
DOI 10.7554/eLife.63518
Indigenous content off
Field of Research 0601 Biochemistry and Cell Biology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149706

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 18 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Wed, 14 Apr 2021, 14:07:26 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.