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Diet quality indices, genetic risk and risk of cardiovascular disease and mortality: a longitudinal analysis of 77 004 UK Biobank participants

Livingstone, Katherine M, Abbott, Gavin, Bowe, Steven J, Ward, Joey, Milte, Catherine and McNaughton, Sarah A 2021, Diet quality indices, genetic risk and risk of cardiovascular disease and mortality: a longitudinal analysis of 77 004 UK Biobank participants, BMJ open, vol. 11, no. 4, pp. 1-12, doi: 10.1136/bmjopen-2020-045362.

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Title Diet quality indices, genetic risk and risk of cardiovascular disease and mortality: a longitudinal analysis of 77 004 UK Biobank participants
Author(s) Livingstone, Katherine MORCID iD for Livingstone, Katherine M orcid.org/0000-0002-9682-7541
Abbott, GavinORCID iD for Abbott, Gavin orcid.org/0000-0003-4014-0705
Bowe, Steven JORCID iD for Bowe, Steven J orcid.org/0000-0003-3813-842X
Ward, Joey
Milte, CatherineORCID iD for Milte, Catherine orcid.org/0000-0003-0035-6405
McNaughton, Sarah AORCID iD for McNaughton, Sarah A orcid.org/0000-0001-5936-9820
Journal name BMJ open
Volume number 11
Issue number 4
Article ID e045362
Start page 1
End page 12
Total pages 12
Publisher BMJ Publishing Group
Place of publication London, Eng.
Publication date 2021-04
ISSN 2044-6055
2044-6055
Keyword(s) coronary heart disease
dietetics
public health
epidemiology
nutrition
nutrition & dietetics
General & Internal Medicine
Life Sciences & Biomedicine
Medicine, General & Internal
Science & Technology
Summary Objectives To examine associations of three diet quality indices and a polygenic risk score with incidence of all-cause mortality, cardiovascular disease (CVD) mortality, myocardial infarction (MI) and stroke. Design Prospective cohort study. Setting UK Biobank, UK. Participants 77 004 men and women (40–70 years) recruited between 2006 and 2010. Main outcome measures A polygenic risk score was created from 300 single nucleotide polymorphisms associated with CVD. Cox proportional HRs were used to estimate independent effects of diet quality and genetic risk on all-cause mortality, CVD mortality, MI and stroke risk. Dietary intake (Oxford WebQ) was used to calculate Recommended Food Score (RFS), Healthy Diet Indicator (HDI) and Mediterranean Diet Score (MDS). Results New all-cause (n=2409) and CVD (n=364) deaths and MI (n=1141) and stroke (n=748) events were identified during mean follow-ups of 7.9 and 7.8 years, respectively. The adjusted HR associated with one-point higher RFS for all-cause mortality was 0.96 (95% CI: 0.94 to 0.98), CVD mortality was 0.94 (95% CI: 0.90 to 0.98), MI was 0.97 (95% CI: 0.95 to 1.00) and stroke was 0.94 (95% CI: 0.91 to 0.98). The adjusted HR for all-cause mortality associated with one-point higher HDI and MDS was 0.97 (95% CI: 0.93 to 0.99) and 0.95 (95% CI: 0.91 to 0.98), respectively. The adjusted HR associated with one-point higher MDS for stroke was 0.93 (95% CI: 0.87 to 1.00). There was little evidence of associations between HDI and risk of CVD mortality, MI or stroke. There was evidence of an interaction between diet quality and genetic risk score for MI. Conclusion Higher diet quality predicted lower risk of all-cause mortality, independent of genetic risk. Higher RFS was also associated with lower risk of CVD mortality and MI. These findings demonstrate the benefit of following a healthy diet, regardless of genetic risk.
Language eng
DOI 10.1136/bmjopen-2020-045362
Indigenous content off
Field of Research 1103 Clinical Sciences
1117 Public Health and Health Services
1199 Other Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 1173803
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149890

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.