Piperine: a review of its biological effects

Haq, IU, Imran, M, Nadeem, M, Tufail, T, Gondal, Tanweer Aslam and Mubarak, MS 2021, Piperine: a review of its biological effects, Phytotherapy research, vol. 35, no. 2, pp. 680-700, doi: 10.1002/ptr.6855.

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Title Piperine: a review of its biological effects
Author(s) Haq, IU
Imran, M
Nadeem, M
Tufail, T
Gondal, Tanweer Aslam
Mubarak, MS
Journal name Phytotherapy research
Volume number 35
Issue number 2
Start page 680
End page 700
Total pages 21
Publisher Wiley
Place of publication Chichester, Eng.
Publication date 2021-02
ISSN 0951-418X
1099-1573
Keyword(s) black pepper
cancer prevention
metabolic syndromes
Piper nigrum
piperine
Summary Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti-obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti-allergic, anti-inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health-promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.
Language eng
DOI 10.1002/ptr.6855
Field of Research 03 Chemical Sciences
06 Biological Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30149901

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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